Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population
Table 5
SIRT6 tagSNPs in association with diseased vessel ().
Type
1VD and 2VD ()
3VD ()
OR (95% CI)
Number (%)
Number (%)
rs11878868
G
530 (90.8)
326 (89.6)
0.364
0.546
1
0.563
T
54 (9.2)
38 (10.4)
1.14 (0.73–1.80)
GG
240 (82.2)
145 (79.7)
0.467
0.494
1
0.501
GT + TT
52 (17.8)
37 (20.3)
1.18 (0.73–1.90)
rs107251
C
405 (69.3)
264 (72.5)
1.091
0.296
1
0.463
T
179 (30.7)
100 (27.5)
0.89 (0.66–1.21)
CC
139 (47.6)
93 (51.1)
0.548
0.459
1
0.647
CT + TT
153 (52.4)
89 (48.9)
0.92 (0.63–1.34)
rs352493
T
462 (79.1)
259 (71.2)
7.793
0.005
1
0.013
C
122 (20.9)
105 (28.8)
1.47 (1.09–2.00)
TT
183 (62.7)
94 (51.6)
5.609
0.018
1
0.031
CC + CT
109 (37.3)
88 (48.4)
1.52 (1.04–2.24)
rs4807546
T
360 (61.6)
236 (64.8)
0.978
0.232
1
0.443
C
224 (38.4)
128 (35.2)
0.90 (0.68–1.18)
TT
109 (37.3)
80 (44.0)
2.054
0.152
1
0.177
CT + CC
183 (62.7)
102 (56.0)
0.77 (0.52–1.13)
rs3760908
A
221 (37.8)
165 (45.3)
5.208
0.022
1
0.046
G
363 (62.2)
199 (54.7)
0.76 (0.59–1.00)
AA
44 (15.1)
42 (23.1)
4.842
0.028
1
0.054
GG + AG
248 (84.9)
140 (76.9)
0.62 (0.38–1.01)
1VD: 1-vessel disease; 2VD: 2-vessel disease; 3VD: 3-vessel disease. values under 0.05 were indicated in bold font. The values and OR were adjusted for age, sex, smoking, drinking, hypertension, diabetes, and hyperlipidemia.
