Overexpression of Prolyl-4-Hydroxylase-α1 Stabilizes but Increases Shear Stress-Induced Atherosclerotic Plaque in Apolipoprotein E-Deficient Mice

Figure 2

Effect of P4Ha1 overexpression on collagen content in plaques. (a) Representative collagen staining in the two different shear stress regions in three groups of mice. (b) Quantitative analysis of plaque collagen contents in the two different shear stress regions in three groups of mice. (c) Quantitative analysis of fibrous cap thickness in the two different shear stress regions in three groups of mice. (d) Western blot analysis of TGF-β1 protein expression with lenti-P4Ha1, lenti-EGFP, and mock ( versus mock; versus mock; versus lenti-EGFP; versus lenti-EGFP).

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