Evaluation of MTBDRplus and MTBDRsl in Detecting Drug-Resistant Tuberculosis in a Chinese Population

Table 4

Performance of GenoType MTBDRplus and GenoType MTBDRsl according to the conventional DST.

Conventional DST ()	GenoType MTBDRplus and GenoType MTBDRsl
	R	S	INV	Se (%)	Sp (%)	PLR	NLR	Agr (%)	Kappa
RFP
R (91)	91	0	0
S (8)	4	4	0
Total (99)	95	4	0	100	50	2	0	95.96	0.65	<0.001
INH
R (82)	62	10	10
S (17)	9	8	0
Total (99)	71	18	10	86.11	47.06	1.63	0.30	78.65	0.32	0.001
OFX
R (38)	36	2	0
S (54)	4	50	0
NA (7)	3	4	0	94.74	92.59	12.79	0.06	93.48	0.87	<0.001
Total (99)	43	56	0
Km
R ()	5	3	0
S (84)	1	83	0
NA ()	2	5	0	62.50	98.81	52.50	0.38	95.65	0.69	<0.001
Total (99)	8	86	0
EMB
R (51)	30	21	0
S (48)	4	44	0
Total (99)	34	65	0	58.82	91.67	7.06	0.45	74.75	0.50	<0.001

R: resistant; S: sensitive; NA: not available; Se: sensitivity; Sp: specificity; INV: invalid; PLR: positive likelihood ratio; NLR: negative likelihood ratio; Agr: agreement.
Seven strains with very weak inhA locus control bands and 3 strains without katG control bands were identified as invalid results.
Significant test for Kappa.