Disease Markers / 2016 / Article / Tab 4

Research Article

Evaluation of MTBDRplus and MTBDRsl in Detecting Drug-Resistant Tuberculosis in a Chinese Population

Table 4

Performance of GenoType MTBDRplus and GenoType MTBDRsl according to the conventional DST.

Conventional DST ()GenoType MTBDRplus and GenoType MTBDRsl
RSINVSe (%)Sp (%)PLRNLRAgr (%)Kappa

RFP
 R (91)9100
 S (8)440
 Total (99)9540100502095.960.65<0.001
INH
 R (82)621010
 S (17)980
 Total (99)71181086.1147.061.630.3078.650.320.001
OFX
 R (38)3620
 S (54)4500
 NA (7)34094.7492.5912.790.0693.480.87<0.001
 Total (99)43560
Km
 R ()530
 S (84)1830
 NA ()25062.5098.8152.500.3895.650.69<0.001
 Total (99)8860
EMB
 R (51)30210
 S (48)4440
 Total (99)3465058.8291.677.060.4574.750.50<0.001

R: resistant; S: sensitive; NA: not available; Se: sensitivity; Sp: specificity; INV: invalid; PLR: positive likelihood ratio; NLR: negative likelihood ratio; Agr: agreement.
Seven strains with very weak inhA locus control bands and 3 strains without katG control bands were identified as invalid results.
Significant test for Kappa.

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