CYC1 Predicts Poor Prognosis in Patients with Breast Cancer

Figure 4

CYC1 deficiency is responsible for reduced activity of mitochondrial complex III, increased the AMP : ATP ratio, and increased phosphorylation of AMPK. MDA-MB-231 and MDA-MB-435S were treated with control siRNA and CYC1 siRNA; mitochondrial complex III activity, ATP and AMP production, and phosphorylation of AMPK were analyzed in MDA-MB-231 (a, b, c) and MDA-MB-435S (d, e, f). .

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