Expression Profile of p53 and p21 in Large Bowel Mucosa as Biomarkers of Inflammatory-Related Carcinogenesis in Ulcerative Colitis

Figure 1

Regenerative epithelial changes (a) versus low-grade dysplasia (b) in UC. Note in (a) preservation of crypt architecture as well as nuclear polarization. In (b) crypt is distorted and epithelial cells have lost nuclear polarity.

(a)

(b)