Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2016, Article ID 3625279, 7 pages
http://dx.doi.org/10.1155/2016/3625279
Research Article

Expression Profile of p53 and p21 in Large Bowel Mucosa as Biomarkers of Inflammatory-Related Carcinogenesis in Ulcerative Colitis

1Colentina University Hospital, 020125 Bucharest, Romania
2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Received 8 April 2016; Accepted 5 July 2016

Academic Editor: Caterina Longo

Copyright © 2016 Cristiana Popp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Danese, M. Sans, and C. Fiocchi, “Inflammatory bowel disease: the role of environmental factors,” Autoimmunity Reviews, vol. 3, no. 5, pp. 394–400, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. N. A. Molodecky, I. S. Soon, D. M. Rabi et al., “Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review,” Gastroenterology, vol. 142, no. 1, pp. 46–54, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. C. N. Bernstein and F. Shanahan, “Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases,” Gut, vol. 57, no. 9, pp. 1185–1191, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. J. A. Eaden, K. R. Abrams, and J. F. Mayberry, “The risk of colorectal cancer in ulcerative colitis: a meta-analysis,” Gut, vol. 48, no. 4, pp. 526–535, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. F. A. Farraye, R. D. Odze, J. Eaden, and S. H. Itzkowitz, “AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease,” Gastroenterology, vol. 138, no. 2, pp. 746–774.e4, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Magro, C. Langner, A. Driessen et al., “European consensus on the histopathology of inflammatory bowel disease,” Journal of Crohn's and Colitis, vol. 7, no. 10, pp. 827–851, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. R. M. Feakins, “Inflammatory bowel disease biopsies: updated British Society of Gastroenterology Reporting Guidelines,” Journal of Clinical Pathology, vol. 66, no. 12, pp. 1005–1026, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Hemminki, X. Li, J. Sundquist, and K. Sundquist, “Cancer risks in ulcerative colitis patients,” International Journal of Cancer, vol. 123, no. 6, pp. 1417–1421, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. N. Ananthakrishnan, A. Cagan, T. Cai et al., “Colonoscopy is associated with a reduced risk for colon cancer and mortality in patients with inflammatory bowel diseases,” Clinical Gastroenterology and Hepatology, vol. 13, no. 2, pp. 322–329, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. S. H. Itzkowitz, D. H. Present, V. Binder et al., “Consensus conference: colorectal cancer screening and surveillance in inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 11, no. 3, pp. 314–321, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Annaházi and T. Molnár, “Pathogenesis of ulcerative colitis and Crohn's disease: similarities, differences and a lot of things we do not know yet,” Journal of Clinical & Cellular Immunology, vol. 5, article 253, 2014. View at Publisher · View at Google Scholar
  12. S. Danese and C. Fiocchi, “Ulcerative colitis,” The New England Journal of Medicine, vol. 365, no. 18, pp. 1713–1725, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. S. P. Hussain, P. Amstad, K. Raja et al., “Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease,” Cancer Research, vol. 60, no. 13, pp. 3333–3337, 2000. View at Google Scholar · View at Scopus
  14. S. Itzkowitz, “Colon carcinogenesis in inflammatory bowel disease: applying molecular genetics to clinical practice,” Journal of Clinical Gastroenterology, vol. 36, no. 5, pp. S70–S74, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. D. T. Rubin, D. Huo, J. A. Rothe et al., “Increased inflammatory activity is an independent risk factor for dysplasia and colorectal cancer in ulcerative colitis: a case-control analysis with blinded prospective pathology review,” Gastroenterology, vol. 130, article A2, 2006. View at Google Scholar
  16. E. Ierardi, M. Principi, R. Francavilla et al., “Epithelial proliferation and ras p21 oncoprotein expression in rectal mucosa of patients with ulcerative colitis,” Digestive Diseases and Sciences, vol. 46, no. 5, pp. 1083–1087, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. N. A. C. S. Wong, N. J. Mayer, C. E. Anderson et al., “Cyclin D1 and p21WAF1/CIP1 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms,” Human Pathology, vol. 34, no. 6, pp. 580–588, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. M. P. Bronner, C. Culin, J. C. Reed, and E. E. Furth, “The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model,” American Journal of Pathology, vol. 146, no. 1, pp. 20–26, 1995. View at Google Scholar · View at Scopus
  19. P. Kinra, S. P. V. Turlapati, A. Mehta, and R. Rai, “Study of p53 and bcl-2 oncoproteins in ulcerative colitis with dysplasia,” Medical Journal Armed Forces India, vol. 61, no. 2, pp. 125–129, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. J. K. Triantafillidis, G. Nasioulas, and P. A. Kosmidis, “Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies,” Anticancer Research, vol. 29, no. 7, pp. 2727–2737, 2009. View at Google Scholar · View at Scopus
  21. S. Sunkara, G. Swanson, C. B. Forsyth, and A. Keshavarzian, “Chronic inflammation and malignancy in ulcerative colitis,” Ulcers, vol. 2011, Article ID 714046, 8 pages, 2011. View at Publisher · View at Google Scholar
  22. R. H. Riddell, H. Goldman, D. F. Ransohoff et al., “Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications,” Human Pathology, vol. 14, no. 11, pp. 931–968, 1983. View at Publisher · View at Google Scholar · View at Scopus
  23. S. C. Truelove and L. J. Witts, “Cortisone in ulcerative colitis; final report on a therapeutic trial,” British Medical Journal, vol. 2, no. 4947, pp. 1041–1048, 1955. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Moser, “How often do patients with IBD have symptom recurrence?” Inflammatory Bowel Diseases, vol. 14, article S47, 2008. View at Google Scholar · View at Scopus
  25. G. Bresci, G. Parisi, M. Bertoni, and A. Capria, “Long-term maintenance treatment in ulcerative colitis: a 10-year follow-up,” Digestive and Liver Disease, vol. 34, no. 6, pp. 419–423, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. R. D. Cohen, D. M. Woseth, R. A. Thisted, and S. B. Hanauer, “A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis,” American Journal of Gastroenterology, vol. 95, no. 5, pp. 1263–1276, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. J. M. Richter, S. Kushkuley, J. A. Barrett, and G. Oster, “Treatment of new-onset ulcerative colitis and ulcerative proctitis: a retrospective study,” Alimentary Pharmacology & Therapeutics, vol. 36, no. 3, pp. 248–256, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Ordás, L. Eckmann, M. Talamini, D. C. Baumgart, and W. J. Sandborn, “Ulcerative colitis,” The Lancet, vol. 380, no. 9853, pp. 1606–1619, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. P. May and E. May, “Twenty years of p53 research: structural and functional aspects of the p53 protein,” Oncogene, vol. 18, no. 53, pp. 7621–7636, 1999. View at Google Scholar
  30. A. L. Gartel and S. K. Radhakrishnan, “Lost in transcription: p21 repression, mechanisms, and consequences,” Cancer Research, vol. 65, no. 10, pp. 3980–3985, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Mitsuhashi, T. Mikami, K. Saigenji, and I. Okayasu, “Significant correlation of morphological remodeling in ulcerative colitis with disease duration and between elevated p53 and p21WAF1 expression rectal mucosa and neoplastic development,” Pathology International, vol. 55, no. 3, pp. 113–121, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Sato and R. Machinami, “p53 Immunohistochemistry of ulcerative colitis-associated with dysplasia and carcinoma,” Pathology International, vol. 49, no. 10, pp. 858–868, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. G. P. Christophi, R. Rong, P. G. Holtzapple, P. T. Massa, and S. K. Landas, “Immune markers and differential signaling networks in ulcerative colitis and Crohn's disease,” Inflammatory Bowel Diseases, vol. 18, no. 12, pp. 2342–2356, 2012. View at Publisher · View at Google Scholar · View at Scopus