Concentration and Methylation of Cell-Free DNA from Blood Plasma as Diagnostic Markers of Renal Cancer

Table 3

Summary of clinicopathological characteristics of patients with RCC and methylation status of LRRC3B, RASSF1, FHIT, and APC CpG islands in cfDNA.

Number	Pathology	Age (y)	Sex	pTNM	Clinical grade	Fuhrman nuclear grade	Methylation
							LRRC3B	RASSF1	APC	FHIT
1	ccRCC	54	M	рТ2N0M0	II	3	+	+	−	+
2	ccRCC	61	M	Т1N0M0	II	2	+	+	−	+
3	Sarcoma-like	66	F	рТ2N0MX	II	3	+	−	+	+
4	Papillary/ccRCC	63	M	рТ1вN0MX	III	1	−	+	−	+
5	ccRCC	47	F	рТ3аN0M1	III	3	+	+	+	+
6	ccRCC	64	M	рТ3аN0M1	III	3	+	+	+	+
7	ccRCC	58	M	рТ2N0MX	III	3	+	−	+	−
8	ccRCC	61	M	рТ1вN0M0	III	2	+	+	−	−
9	ccRCC	75	M	рТ1вN0MX	III	2	−	+	−	+
10	ccRСС	65	M	T2N0MX	III	3	−	+	+	+
11	ccRCC	61	F	pT1N0M0	III	2	+	−	+	−
12	ccRCC	63	F	рТ3аN1MX	III	2-3	+	−	+	−
13	ccRCC	68	F	pT1 N0 MX	III	1-2	+	−	+	+
14	ccRCC	34	M	рТ1аN0 MX	III	1	+	−	+	−
15	Cancer of the renal pelvis	76	M	pT3N0M1	III	4	+	+	+	+
16	ccRCC	56	F	рТ1аN0MX	III	1	−	−	+	+
17	ccRCC	62	F	рТ1аN0MX	III	1	+	−	+	+
18	ccRCC	46	F	рТ1вN0MX	III	1	+	+	−	−
19	ccRCC	55	F	рТ2N0MX	III	2	+	+	+	−
20	ccRCC	45	F	T2N0M0	II	2	−	+	−	−
21	ccRCC	61	F	рТ1аN0MX	III	2	+	+	−	−
22	ccRCC	60	M	NA	III	2	+	+	−	+
23	ccRCC	63	F	рТ1вN0MX	III	2	+	−	−	−
24	Sarcoma-like	60	F	NA	III	4	+	−	−	−
25	ccRCC	45	M	pT1вN0MX	III	2	−	+	+	+
26	ccRCC	63	M	рТ1аN0M0	III	1	+	+	−	+
27	ccRCC	73	F	рТ1аN0M0	III	1	−	+	−	−

The results in the Table are presented only for the genes with detected aberrant methylation in cfDNA.