Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2016, Article ID 4358292, 6 pages
http://dx.doi.org/10.1155/2016/4358292
Research Article

GSTP1 Methylation and Protein Expression in Prostate Cancer: Diagnostic Implications

1Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014 Meldola, Italy
2University of Florence, 50121 Florence, Italy
3Pathology Unit, Morgagni-Pierantoni Hospital, 47121 Forlì, Italy
4Department of Urology, Morgagni-Pierantoni Hospital, 47121 Forlì, Italy
5Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014 Meldola, Italy
6Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014 Meldola, Italy

Received 17 February 2016; Revised 21 June 2016; Accepted 3 July 2016

Academic Editor: Carmen Jeronimo

Copyright © 2016 Filippo Martignano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Laborde, “Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death,” Cell Death and Differentiation, vol. 17, no. 9, pp. 1373–1380, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Singh, “Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death,” Cancer Chemotherapy and Pharmacology, vol. 75, no. 1, pp. 1–15, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Sarkar, G. Horn, K. Moulton et al., “Cancer development, progression, and therapy: an epigenetic overview,” International Journal of Molecular Sciences, vol. 14, no. 10, pp. 21087–21113, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Vecchio, P. F. Seke Etet, M. J. Kipanyula, M. Krampera, and A. H. Nwabo Kamdje, “Importance of epigenetic changes in cancer etiology, pathogenesis, clinical profiling, and treatment: what can be learned from hematologic malignancies?” Biochimica et Biophysica Acta (BBA)—Reviews on Cancer, vol. 1836, no. 1, pp. 90–104, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Casadio, C. Molinari, D. Calistri et al., “DNA methylation profiles as predictors of recurrence in non muscle invasive bladder cancer: an MS-MLPA approach,” Journal of Experimental & Clinical Cancer Research, vol. 32, article 94, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Gumy-Pause, B. Pardo, M. Khoshbeen-Boudal et al., “GSTP1 hypermethylation is associated with reduced protein expression, aggressive disease and prognosis in neuroblastoma,” Genes Chromosomes and Cancer, vol. 51, no. 2, pp. 174–185, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. Q. F. Li, Q. Y. Li, A. R. Gao, and Q. F. Shi, “Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis,” Genetics and Molecular Research, vol. 14, no. 2, pp. 6762–6772, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Fiolka, P. Zubor, V. Janusicova et al., “Promoter hypermethylation of the tumor-suppressor genes RASSF1A, GSTP1 and CDH1 in endometrial cancer,” Oncology Reports, vol. 30, no. 6, pp. 2878–2886, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Fang, X.-M. Wei, X.-T. Zeng, F.-B. Wang, H. Weng, and X. Long, “Aberrant GSTP1 promoter methylation is associated with increased risk and advanced stage of breast cancer: a meta-analysis of 19 case-control studies,” BMC Cancer, vol. 15, article 920, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Goering, M. Kloth, and W. A. Schulz, “DNA methylation changes in prostate cancer,” Methods in Molecular Biology, vol. 863, pp. 47–66, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Schnekenburger, T. Karius, and M. Diederich, “Regulation of epigenetic traits of the glutathione S-transferase P1 gene: from detoxification toward cancer prevention and diagnosis,” Frontiers in Pharmacology, vol. 5, article 170, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. V. L. Costa, R. Henrique, and C. Jerónimo, “Epigenetic markers for molecular detection of prostate cancer,” Disease Markers, vol. 23, no. 1-2, pp. 31–41, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Andrés, N. Ashour, M. Sánchez-Chapado, S. Ropero, and J. C. Angulo, “The study of DNA methylation in urological cancer: present and future,” Actas Urologicas Espanolas, vol. 37, no. 6, pp. 368–375, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Jiang, Y. Shen, D. Dai et al., “Meta-analyses of methylation markers for prostate cancer,” Tumor Biology, vol. 35, no. 10, pp. 10449–10455, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Henrique and C. Jerónimo, “Molecular detection of prostate cancer: a role for GSTP1 hypermethylation,” European Urology, vol. 46, no. 5, pp. 660–669, 2004. View at Publisher · View at Google Scholar
  16. W. Zhang, H. Jiao, X. Zhang et al., “Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer,” Molecular Medicine Reports, vol. 12, no. 1, pp. 141–146, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Lin, M. Tascilar, W.-H. Lee et al., “GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells,” The American Journal of Pathology, vol. 159, no. 5, pp. 1815–1826, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. D. G. Bostwick, L. Liu, M. K. Brawer, and J. Qian, “High-grade prostatic intraepithelial neoplasia,” Reviews in Urology, vol. 6, pp. 171–179, 2004. View at Google Scholar
  19. G. H. Kang, S. Lee, H. J. Lee, and K. S. Hwang, “Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia,” The Journal of Pathology, vol. 202, no. 2, pp. 233–240, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. J. I. Epstein, L. Egevad, P. A. Humphrey et al., “Best practices recommendations in the application of immunohistochemistry in the prostate: report from the International Society of Urologic Pathology Consensus Conference,” The American Journal of Surgical Pathology, vol. 38, no. 8, pp. e6–e19, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. V. Singh, V. Manu, A. Malik, V. Dutta, N. S. Mani, and S. Patrikar, “Diagnostic utility of p63 and α-methyl acyl Co A racemase in resolving suspicious foci in prostatic needle biopsy and transurethral resection of prostate specimens,” Journal of Cancer Research and Therapeutics, vol. 10, no. 3, pp. 686–692, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Kuroda, “Application of combined immunohistochemical panel of AMACR(P504S)/p63 cocktail, cytokeratin 5 and D2-40 to atypical glands in prostatic needle biopsy,” Malaysian Journal of Pathology, vol. 36, no. 3, pp. 169–173, 2014. View at Google Scholar · View at Scopus
  23. L. Sawers, M. J. Ferguson, B. R. Ihrig et al., “Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines,” British Journal of Cancer, vol. 111, no. 6, pp. 1150–1158, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. W.-H. Lee, R. A. Morton, J. I. Epstein et al., “Cytidine methylation of regulatory sequences near the π-class glutathione S-transferase gene accompanies human prostatic carcinogenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 24, pp. 11733–11737, 1994. View at Publisher · View at Google Scholar · View at Scopus
  25. W.-H. Lee, W. B. Isaacs, G. S. Bova, and W. G. Nelson, “CG island methylation changes near the GSTP1 gene in prostatic carcinoma cells detected using the polymerase chain reaction: a new prostate cancer biomarker,” Cancer Epidemiology, Biomarkers & Prevention, vol. 6, no. 6, pp. 443–450, 1997. View at Google Scholar · View at Scopus
  26. L. Van Neste, J. G. Herman, G. Otto, J. W. Bigley, J. I. Epstein, and W. Van Criekinge, “The epigenetic promise for prostate cancer diagnosis,” The Prostate, vol. 72, no. 11, pp. 1248–1261, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Wu, E. Giovannucci, J. Welge, P. Mallick, W.-Y. Tang, and S.-M. Ho, “Measurement of GSTP1 promoter methylation in body fluids may complement PSA screening: a meta-analysis,” British Journal of Cancer, vol. 105, no. 1, pp. 65–73, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Zelic, V. Fiano, D. Zugna et al., “Global hypomethylation (LINE-1) and gene-specific hypermethylation (GSTP1) on initial negative prostate biopsy as markers of prostate cancer on a rebiopsy,” Clinical Cancer Research, vol. 22, no. 4, pp. 984–992, 2016. View at Publisher · View at Google Scholar
  29. V. Sailer, H. L. K. Eberhard, C. Stephan et al., “Glutathione S-transferase-pi protein expression in prostate cancer-not always a useful diagnostic tool,” Histopathology, vol. 67, no. 4, pp. 577–579, 2015. View at Publisher · View at Google Scholar · View at Scopus