Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis

Table 1

Subject characteristics.

	IPF	BP	HC
Subjects ()	65	31	101
Age, yr	69.3 ± 8.5	67.8 ± 15.0	55.9 ± 2.3
Sex, M/F	50/15	21/10	76/25
Pack-years	37.6 ± 35.4	21.5 ± 26.7	13.7 ± 21.0
Spirometry
% VC, %	74.5 ± 21.2	—	109.5 ± 13.2
FEV1/FVC, %	83.5 ± 17.0	—	80.6 ± 4.9
% D, %	47.1 ± 15.8	—	—

IPF: idiopathic pulmonary fibrosis, BP: bacterial pneumonia, HC: healthy controls, VC: vital capacity, FEV₁: forced expiratory volume in 1 second, FVC: forced vital capacity, and D: diffusing capacity of the lung for carbon monoxide.
Data represent the mean SD.
Significant differences versus the HC were evaluated using Mann-Whitney test.
< 0.001 and < 0.0001.