Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis
Table 3
Cox proportional hazards model to predict the 5-year mortality of patients with IPF.
Variables
HR
95% CI
value
Univariate analysis
MMP-7 (continuous)
1.068
1.015–1.124
0.0109
CCL18 (continuous)
1.007
0.999–1.014
0.0734
KL-6 (continuous)
1.001
1.000–1.001
0.0005
SP-A (continuous)
1.006
0.999–1.015
0.1143
SP-D (continuous)
1.000
0.998–1.002
0.9180
Age
1.032
0.982–1.085
0.2128
Sex, M
2.163
0.734–6.370
0.1616
Smoking
1.468
0.546–3.951
0.4471
% VC (continuous)
0.965
0.942–0.989
0.0040
Medication
2.730
1.177–6.333
0.0193
Multivariate analysis
MMP-7 (continuous)
1.074
1.060–1.147
0.0336
KL-6 (continuous)
1.001
1.000–1.002
0.0042
% VC (continuous)
0.981
0.954–1.009
0.1744
Medication
2.066
0.667–6.399
0.2086
See legends of Tables 1 and 2 for expansion of abbreviations. Medication indicates the usage of corticosteroids and/or immunosuppressants. Multivariate Cox analysis was adjusted for age, sex, and smoking history.
