Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

Table 3

Univariate and multivariate Cox proportional hazard regression analyses for all-cause, cardiovascular, and noncardiovascular mortality.

Variables	Unadjusted			Adjusted
	HR	95% CI	value	HR	95% CI	value
All-cause mortality
High AST/ALT ratio	2.70	2.00–3.65	<0.0001		1.06–2.00	0.0190
					1.04–1.96	0.0284
Cardiovascular mortality
High AST/ALT ratio	4.35	2.65–7.09	<0.0001		1.30–3.69	0.0031
					1.49–4.24	0.0006
Noncardiovascular mortality
High AST/ALT ratio	2.12	1.44–3.13	0.0001		0.79–1.77	0.4109
					0.75–1.69	0.5800

Adjusted for age, gender, consumption of alcohol, smoking, hypertension, diabetes mellitus, and eGFR.
Adjusted for age, gender, body mass index, previous cardiovascular disease, diabetes mellitus, eGFR, and BNP.
ALT, alanine transaminase; AST, aspartate transaminase; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio.