Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up
Table 5
Clinical characteristics between subjects with high and low AST/ALT ratio.
Variables
Low AST/ALT ratio
High AST/ALT ratio
value
Age (years)
62 ± 10
68 ± 11
<0.0001
Men/women
160/177
1402/1755
0.2815
BMI, kg/cm2
23.7 ± 3.1
22.1 ± 3.1
<0.0001
Previous CVD, (%)
380 (12%)
79 (22%)
<0.0001
Previous cancer, (%)
62 (2%)
12 (3%)
0.0869
Previous liver disease, (%)
73 (2%)
9 (3%)
0.8255
Smoking, (%)
998 (32%)
123 (34%)
0.3306
Alcohol consumption, (%)
1291 (41%)
163 (46%)
0.1125
Hypertension, (%)
1134 (36%)
144 (40%)
0.1305
Diabetes mellitus, (%)
229 (7%)
12 (3%)
0.0052
Systolic BP, mmHg
134 ± 16
135 ± 17
0.4902
Diastolic BP, mmHg
80 ± 10
78 ± 10
0.0050
HbA1c, %
5.7 ± 0.7
5.5 ± 0.5
<0.0001
FBS, mg/dL
95 ± 17
92 ± 12
0.0004
eGFR, mL/min/1.73 m2
82 ± 16
77 ± 16
<0.0001
Log H-FABP, ng/mL
1.23 ± 0.43
1.34 ± 0.45
<0.0001
Log BNP, pg/mL
2.95 ± 0.84
3.42 ± 0.90
<0.0001
AST, IU/L
24.8 ± 9.7
27.4 ± 25
0.0002
ALT, IU/L
24.3 ± 13.8
15.0 ± 13.2
<0.0001
-GTP, IU/L
36 ± 45
34 ± 66
0.3455
Data are expressed as mean ± standard deviation or number (%). ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; BNP, brain natriuretic peptide; BP, blood pressure; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; FBS, fasting blood sugar; -GTP, gamma glutamyl transpeptidase; HbA1c, glycosylated hemoglobin A1c; H-FABP, heart type fatty acid binding protein.
