Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of Patients with Gastric Cancer

Table 4

Correlation between OSR2, VAV3, and PPFIA3 hypermethylation status in serum of GC patients and clinicopathological parameters.

Parameters	Number of cases	OSR2		VAV3		PPFIA3
		Methylation	value	Methylation	value	Methylation	value
Age
<60	26	16 (61.5%)	0.881	13 (50.0%)	0.529	14 (53.8%)	0.715
≥60	22	14 (63.6%)		9 (40.9%)		13 (59.1%)
Gender
Male	39	23 (59.0%)	0.504	19 (48.7%)	0.186	23 (59.0%)	0.675
Female	9	7 (77.8%)		3 (33.3%)		4 (44.4%)
Pathological differentiation
Well + moderate	19	13 (68.4%)	0.493	7 (36.8%)	0.583	11 (57.9%)	0.853
Poor + undifferentiation	29	17 (58.6%)		13 (44.8%)		16 (55.2%)
Depth of tumor invasion
Tis, T1a, T1b	5	2 (40.0%)	0.663	2 (40.0%)	0.645	2 (40.0%)	0.694
T2	7	5 (71.4%)		2 (28.6%)		3 (42.9%)
T3	12	7 (58.3%)		7 (58.3%)		7 (58.3%)
T4a, T4b	24	16 (66.7%)		11 (45.8%)		15 (62.4%)
Lymph node metastasis
N0	16	9 (56.3%)	0.492	5 (31.3%)	0.430	8 (50.0%)	0.514
N1	15	8 (53.3%)		7 (46.7%)		7 (46.7%)
N2	6	5 (83.3%)		4 (66.7%)		4 (66.7%)
N3a, N3b	11	8 (72.7%)		6 (54.5%)		8 (72.7%)
TNM stages
I and II	22	13 (59.1%)	0.881	8 (36.4%)	0.019	10 (45.5%)	0.165
III and IV	26	17 (65.4%)		14 (53.8%)		17 (65.4%)

Using chi-square for this statistic.
Statistically significant.