Detection of Autoantibodies to Vascular Endothelial Growth Factor Receptor-3 in Bile Duct Ligated Rats and Correlations with a Panel of Traditional Markers of Liver Diseases

Table 1

Measurements of traditional markers of liver injury and cholestasis in serum and fibrosis in the liver.

	Control	Sham			BDL
	()	Week 1 ()	Week 3 ()	Week 5 ()	Week 1 ()	Week 3 ()	Week 5 ()
Liver/body weight ratio (%)	3.98 ± 0.32	3.87 ± 0.47	4.07 ± 0.17	3.68 ± 0.32	5.35 ± 0.40	6.99 ± 1.02	6.84 ± 0.65
AST (U/L)	141.20 ± 13.93	160.20 ± 37.16	117.40 ± 22.07	126.20 ± 23.79	862.83 ± 394.96	974.71 ± 330.69	1084 ± 607.64
ALT (U/L)	71.60 ± 13.05	71.80 ± 14.86	67.60 ± 13.13	72.20 ± 18.30	172.83 ± 69.08	139.57 ± 49.43	176.25 ± 81.89
TB (mg/dL)	0.12 ± 0.05	0.10 ± 00.00	0.10 ± 00.00	0.08 ± 0.05	7.62 ± 2.68	8.97 ± 1.77	8.95 ± 2.32
Relative fibrotic area (%)	0.4292 ± 0.1239	0.45 ± 0.15	0.50 ± 0.05	0.45 ± 0.11	0.84 ± 0.19	8.33 ± 1.20	17.17 ± 0.33

Data were expressed as mean ± standard deviation. for BDL and sham groups versus control group; for BDL groups versus equivalent sham groups; and for BDL at week 3 versus BDL at week 1 and BDL at week 5 versus BDL at week 3. ALT: alanine aminotransferase; AST: aspartate aminotransferase; BDL: bile duct ligation; TB: total bilirubin.