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Disease Markers
Volume 2016, Article ID 7068986, 8 pages
http://dx.doi.org/10.1155/2016/7068986
Research Article

miR-1 Inhibits Cell Growth, Migration, and Invasion by Targeting VEGFA in Osteosarcoma Cells

1Department of Radiology, Zhengzhou Orthopedics Hospital, Zhengzhou, China
2Department of Minimally Invasive Spine Surgery, Zhengzhou Orthopedics Hospital, Zhengzhou, China
3Zhengzhou Key Laboratory of Bone and Joint Imaging, Zhengzhou, China
4Department of Radiology, Zhengzhou Second Hospital, Zhengzhou, China
5Department of Function, Zhengzhou Orthopedics Hospital, Zhengzhou, China

Received 11 May 2016; Accepted 28 August 2016

Academic Editor: Gad Rennert

Copyright © 2016 Junjie Niu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Gill, M. K. Ahluwalia, D. Geller, and R. Gorlick, “New targets and approaches in osteosarcoma,” Pharmacology and Therapeutics, vol. 137, no. 1, pp. 89–99, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. D. C. Allison, S. C. Carney, E. R. Ahlmann et al., “A meta-analysis of osteosarcoma outcomes in the modern medical era,” Sarcoma, vol. 2012, Article ID 704872, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Romano, M. Acunzo, M. Garofalo et al., “MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 41, pp. 16570–16575, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. L. P. Lim, N. C. Lau, P. Garrett-Engele et al., “Microarray analysis shows that some microRNAs downregulate large numbers of-target mRNAs,” Nature, vol. 433, no. 7027, pp. 769–773, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. P. Bartel, “MicroRNAs: genomics, biogenesis, mechanism, and function,” Cell, vol. 116, no. 2, pp. 281–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Weiss, L. Brandenburg, M. Burchardt, and M. B. Stope, “MicroRNA-1 properties in cancer regulatory networks and tumor biology,” Critical Reviews in Oncology/Hematology, vol. 104, pp. 71–77, 2016. View at Publisher · View at Google Scholar
  7. Y.-N. Liu, J. J. Yin, W. Abou-Kheir et al., “MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms,” Oncogene, vol. 32, no. 3, pp. 296–306, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Montanini, L. Lasagna, V. Barili et al., “MicroRNA cloning and sequencing in osteosarcoma cell lines: differential role of miR-93,” Cellular Oncology, vol. 35, no. 1, pp. 29–41, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Novello, L. Pazzaglia, C. Cingolani et al., “MiRNA expression profile in human osteosarcoma: role of miR-1 and miR-133b in proliferation and cell cycle control,” International Journal of Oncology, vol. 42, no. 2, pp. 667–675, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. C.-H. Chen, J.-M. Lai, T.-Y. Chou et al., “VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway,” PLoS ONE, vol. 4, no. 4, Article ID e5052, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. J. R. Conejo-Garcia, F. Benencia, M.-C. Courreges et al., “Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A,” Nature Medicine, vol. 10, no. 9, pp. 950–958, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Andreozzi, L. Quagliata, J. R. Gsponer et al., “VEGFA gene locus analysis across 80 human tumour types reveals gene amplification in several neoplastic entities,” Angiogenesis, vol. 17, no. 3, pp. 519–527, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Caporali and C. Emanueli, “MicroRNA regulation in angiogenesis,” Vascular Pharmacology, vol. 55, no. 4, pp. 79–86, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Stahlhut, Y. Suárez, J. Lu, Y. Mishima, and A. J. Giraldez, “miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish,” Development, vol. 139, no. 23, pp. 4356–4365, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Song, Y. Wang, Y. Xi et al., “Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells,” Oncogene, vol. 28, no. 46, pp. 4065–4074, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. C. He, J. Xiong, X. Xu et al., “Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples,” Biochemical and Biophysical Research Communications, vol. 388, no. 1, pp. 35–40, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Bahador, A. Taheriazam, A. Mirghasemi et al., “Tissue expression levels of miR-29b and miR-422a in children, adolescents, and young adults' age groups and their association with prediction of poor prognosis in human osteosarcoma,” Tumor Biology, vol. 37, no. 3, pp. 3091–3095, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Jiang, C. Zhao, X. Yang et al., “miR-1 suppresses the growth of esophageal squamous cell carcinoma in vivo and in vitro through the downregulation of MET, cyclin D1 and CDK4 expression,” International Journal of Molecular Medicine, vol. 38, no. 1, pp. 113–122, 2016. View at Publisher · View at Google Scholar
  19. X. Chen, J. Shi, J. Zhong et al., “MiR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma,” International Journal of Experimental Pathology, vol. 96, no. 6, pp. 427–432, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Minemura, K. Takagi, Y. Miki et al., “Abnormal expression of miR-1 in breast carcinoma as a potent prognostic factor,” Cancer Science, vol. 106, no. 11, pp. 1642–1650, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. M. W. Nasser, J. Datta, G. Nuovo et al., “Down-regulation of micro-RNA-1 (miR-1) in lung cancer: suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1,” Journal of Biological Chemistry, vol. 283, no. 48, pp. 33394–33405, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. H. M. Namløs, L. A. Meza-Zepeda, T. Barøy et al., “Modulation of the osteosarcoma expression phenotype by microRNAs,” PLoS ONE, vol. 7, no. 10, Article ID e48086, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Zhu and W. Wang, “Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1,” Tumor Biology, vol. 37, no. 4, pp. 4373–4382, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. P. S. Ray, J. Jia, P. Yao, M. Majumder, M. Hatzoglou, and P. L. Fox, “A stress-responsive RNA switch regulates VEGFA expression,” Nature, vol. 457, no. 7231, pp. 915–919, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Capp, S. M. Wajner, D. R. Siqueira, B. A. Brasil, L. Meurer, and A. L. Maia, “Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma,” Thyroid, vol. 20, no. 8, pp. 863–871, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Claesson-Welsh and M. Welsh, “VEGFA and tumour angiogenesis,” Journal of Internal Medicine, vol. 273, no. 2, pp. 114–127, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Zhuang and M. Wei, “Impact of vascular endothelial growth factor expression on overall survival in patients with osteosarcoma: a meta-analysis,” Tumor Biology, vol. 35, no. 3, pp. 1745–1749, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Lammli, M. Fan, H. G. Rosenthal et al., “Expression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcoma,” International Orthopaedics, vol. 36, no. 11, pp. 2307–2313, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Carmeliet and R. K. Jain, “Molecular mechanisms and clinical applications of angiogenesis,” Nature, vol. 473, no. 7347, pp. 298–307, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. X.-J. Shao, M.-H. Miao, J. Xue, J. Xue, X.-Q. Ji, and H. Zhu, “The down-regulation of microRNA-497 contributes to cell growth and cisplatin resistance through PI3K/Akt pathway in osteosarcoma,” Cellular Physiology and Biochemistry, vol. 36, no. 5, pp. 2051–2062, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Zhang, C. Zhang, L. Liu, and J. Zhou, “A key role of microRNA-29b in suppression of osteosarcoma cell proliferation and migration via modulation of VEGF,” International Journal of Clinical and Experimental Pathology, vol. 7, no. 9, pp. 5701–5708, 2014. View at Google Scholar · View at Scopus
  32. M. Carleton, M. A. Cleary, and P. S. Linsley, “MicroRNAs and cell cycle regulation,” Cell Cycle, vol. 6, no. 17, pp. 2127–2132, 2007. View at Publisher · View at Google Scholar · View at Scopus