Increased Umbilical Cord PAI-1 Levels in Placental Insufficiency Are Associated with Fetal Hypoxia and Angiogenesis

Figure 2

PAI-1 correlates to the expression of PAI-1 regulators in the fetal umbilical cord blood plasma. (a) In control pregnancies, PAI-1 levels are dependent on total VEGF (i) and FGF-2 (ii) levels (, , and , , resp.), but not venous umbilical oxygen (iii). (b) Conversely in PI pregnancies, PAI-1 expression has no relationship to total VEGF (i) or FGF-2 (ii) levels, but is instead dependant on ambient oxygen levels (iii) (, ) (open: control, closed: PI).

(a)

(b)