Increased Umbilical Cord PAI-1 Levels in Placental Insufficiency Are Associated with Fetal Hypoxia and Angiogenesis

Figure 5

Angiogenic potency correlates to PAI-1 levels in PI. The angiogenic potency of the plasma that was measured (Figure 4) was correlated to PAI-1 and VEGF. (a) In control pregnancies, the angiogenic potency was strongly dependent on total VEGF levels (i) in both measurements of tube formation and branching ( and 0.74, , resp.). However there was no relationship to PAI-1 (ii). (b) Conversely in pregnancies with PI, measure of angiogenesis was unrelated to VEGF levels (i) and, instead, correlated to circulating PAI-1 levels (ii) for both tube formation and branching ( and 0.67, and <0.05, resp.) (open: control, closed: PI).

(a)

(b)