Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2016 (2016), Article ID 7475080, 6 pages
http://dx.doi.org/10.1155/2016/7475080
Research Article

TaqI, FokI, and ApaI Polymorphisms in the Vitamin D Receptor in Behçet’s Disease in Turkish Population

1Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
2Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
3Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey

Received 12 July 2016; Revised 4 August 2016; Accepted 9 August 2016

Academic Editor: Hubertus Himmerich

Copyright © 2016 Gaye Erten et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Behçet, “Uber rezidivierende aphthouse durch ein virus verursachte Geschwuere am Mund, am Auge und an den Genitalien,” Dermatologische Wochenschrift, vol. 105, pp. 1152–1157, 1937. View at Google Scholar
  2. A. Gül, “Pathogenesis of behçet’s disease: autoinflammatory features and beyond,” Seminars in Immunopathology, vol. 37, no. 4, pp. 413–418, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. D. McGonagle and M. F. McDermott, “A proposed classification of the immunological diseases,” PLoS Medicine, vol. 3, no. 8, pp. 1242–1248, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Akman-Demir, P. Serdaroglu, and B. Tasçi, “Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients,” Brain, vol. 122, no. 11, pp. 2171–2182, 1999. View at Publisher · View at Google Scholar
  5. S. Hirohata, “Histopathology of central nervous system lesions in Behçet's disease,” Journal of the Neurological Sciences, vol. 267, no. 1-2, pp. 41–47, 2008. View at Publisher · View at Google Scholar
  6. K. Hamzaoui, I. B. Dhifallah, E. Karray, F. H. Sassi, and A. Hamzaoui, “Vitamin D modulates peripheral immunity in patients with Behçet's disease,” Clinical and Experimental Rheumatology, vol. 28, no. 4, pp. S50–S57, 2010. View at Google Scholar · View at Scopus
  7. S. Karatay, K. Yildirim, A. Karakuzu et al., “Vitamin D status in patients with Behcet's disease,” Clinics, vol. 66, no. 5, pp. 721–723, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. H. F. DeLuca, “Overview of general physiologic features and functions of vitamin D,” The American Journal of Clinical Nutrition, vol. 80, no. 6, pp. 1689S–1696S, 2004. View at Google Scholar
  9. J. M. Lemire, J. S. Adams, R. Sakai, and S. C. Jordan, “1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells,” The Journal of Clinical Investigation, vol. 74, no. 2, pp. 657–661, 1984. View at Publisher · View at Google Scholar
  10. D. M. Provvedini and S. C. Manolagas, “1α,25-dihydroxyvitamin D3 receptor distribution and effects in subpopulations of normal human T lymphocytes,” Journal of Clinical Endocrinology and Metabolism, vol. 68, no. 4, pp. 774–779, 1989. View at Publisher · View at Google Scholar · View at Scopus
  11. V. Mocanu, T. Oboroceanu, and F. Zugun-Eloae, “Current status in vitamin D and regulatory T cells—immunological implications,” Revista Medico-Chirurgicala a Societatii de Medici si Naturalisti din Iasi, vol. 117, no. 4, pp. 965–973, 2013. View at Google Scholar
  12. Y. Tian, C. Wang, Z. Ye, X. Xiao, A. Kijlstra, and P. Yang, “Effect of 1,25-dihydroxyvitamin D3 on Th17 and Th1 response in patients with Behçet's disease,” Investigative Ophthalmology & Visual Science, vol. 53, no. 10, pp. 6434–6441, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Can, M. Gunes, O. A. Haliloglu et al., “Effect of vitamin D deficiency and replacement on endothelial functions in Behçet's disease,” Clinical and Experimental Rheumatology, vol. 30, no. 3, supplement 72, pp. S57–S61, 2012. View at Google Scholar · View at Scopus
  14. J. E. Do, S. Y. Kwon, S. Park, and E.-S. Lee, “Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behçet's disease,” Rheumatology, vol. 47, no. 6, pp. 840–848, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. E. Taymans, S. Pack, E. Pak et al., “The human vitamin D receptor gene (VDR) is localized to region 12cen-q12 by fluorescent in situ hybridization and radiation hybrid mapping: genetic and physical VDR map,” Journal of Bone and Mineral Research, vol. 14, no. 7, pp. 1163–1166, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Xu, B. He, Y. Pan et al., “Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk,” Tumor Biology, vol. 35, no. 5, pp. 4153–4169, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Lykouras, F. Sampsonas, A. Kaparianos, K. Karkoulias, G. Tsoukalas, and K. Spiropoulos, “Human genes in TB infection: their role in immune response,” Monaldi Archives for Chest Disease, vol. 69, no. 1, pp. 24–31, 2008. View at Google Scholar
  18. L. Rolf, A.-H. Muris, R. Hupperts, and J. Damoiseaux, “Vitamin D effects on B cell function in autoimmunity,” Annals of the New York Academy of Sciences, vol. 1317, no. 1, pp. 84–91, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Tizaoui, A. Berraies, B. Hamdi, W. Kaabachi, K. Hamzaoui, and A. Hamzaoui, “Association of vitamin D receptor gene polymorphisms with asthma risk: systematic review and updated meta-analysis of case–control studies,” Lung, vol. 192, no. 6, pp. 955–965, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. T. K. Wöbke, B. L. Sorg, and D. Steinhilber, “Vitamin D in inflammatory diseases,” Frontiers in Physiology, vol. 5, article 244, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Davatchi, S. Assaad-Khalil, K. T. Calamia et al., “The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria,” Journal of the European Academy of Dermatology and Venereology, vol. 28, no. 3, pp. 338–347, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Kolahi, A. Khabbazi, H. Khodadadi et al., “Vitamin D receptor gene polymorphisms in Iranian Azary patients with Behçet's disease,” Scandinavian Journal of Rheumatology, vol. 44, no. 2, pp. 163–167, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Tizaoui, W. Kaabachi, M. Ouled Salah, A. Ben Amor, A. Hamzaoui, and K. Hamzaoui, “Vitamin D receptor TaqI and ApaI polymorphisms: a comparative study in patients with Behçet's disease and Rheumatoid arthritis in Tunisian population,” Cellular Immunology, vol. 290, no. 1, pp. 66–71, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. E. F. Karray, I. Ben Dhifallah, K. Ben Abdelghani et al., “Associations of vitamin D receptor gene polymorphisms FokI and BsmI with susceptibility to rheumatoid arthritis and Behçet's disease in Tunisians,” Joint Bone Spine, vol. 79, no. 2, pp. 144–148, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. O. Kurt, H. Yilmaz-Aydogan, M. Uyar, T. Isbir, M. F. Seyhan, and A. Can, “Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women,” Molecular Biology Reports, vol. 39, no. 6, pp. 6723–6730, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Gogas Yavuz, L. Keskin, S. Kıyıcı et al., “Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients,” Acta Diabetologica, vol. 48, no. 4, pp. 329–336, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Yoldemir, D. G. Yavuz, G. Anik, N. Verimli, and M. Erenus, “Vitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density,” Climacteric, vol. 14, no. 3, pp. 384–391, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. U. Dundar, M. Solak, V. Kavuncu et al., “Evidence of association of Vitamin D receptor Apa I gene polymorphism with bone mineral density in postmenopausal women with osteoporosis,” Clinical Rheumatology, vol. 28, no. 10, pp. 1187–1191, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Tastan, P. H. Kann, H. Tinneberg, P. Hadji, U. Müller-Ladner, and U. Lange, “Low bone mineral density and vitamin d deficiency correlated with genetics and other bone markers in female Turkish immigrants in Germany,” Clinical Rheumatology, 2016. View at Publisher · View at Google Scholar
  30. I. H. Tarner, M. Z. Erkal, B. M. Obermayer-Pietsch et al., “Osteometabolic and osteogenetic pattern of Turkish immigrants in Germany,” Experimental and Clinical Endocrinology and Diabetes, vol. 120, no. 9, pp. 517–523, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Kaleta, J. Bogaczewicz, E. Robak et al., “Vitamin D receptor gene BsmI polymorphism in Polish patients with systemic lupus erythematosus,” ISRN Endocrinology, vol. 2013, Article ID 427818, 5 pages, 2013. View at Publisher · View at Google Scholar
  32. N. Buyru, A. Tezol, E. Yosunkaya-Fenerci, and N. Dalay, “Vitamin D receptor gene polymorphisms in breast cancer,” Experimental and Molecular Medicine, vol. 35, no. 6, pp. 550–555, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Toptaş, A. M. Kafadar, C. Cacina et al., “The vitamin D receptor (VDR) gene polymorphisms in Turkish brain cancer patients,” BioMed Research International, vol. 2013, Article ID 295791, 6 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Dayangac-Erden, A. Karaduman, and H. Erdem-Yurter, “Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients,” Archives of Dermatological Research, vol. 299, no. 10, pp. 487–491, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Goknar, F. Öktem, E. Torun et al., “The role of vitamin D receptor gene polymorphisms in Turkish infants with urolithiasis,” Renal Failure, vol. 38, no. 4, pp. 545–551, 2016. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Gunes, C. Y. Bilen, N. Kara, R. Asci, H. Bagci, and A. F. Yilmaz, “Vitamin D receptor gene polymorphisms in patients with urolithiasis,” Urological Research, vol. 34, no. 1, pp. 47–52, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. O. O. Cakir, A. Yilmaz, E. Demir, K. Incekara, M. O. Kose, and N. Ersoy, “Association of the BsmI, ApaI, TaqI, Tru9I and FokI polymorphisms of the vitamin D receptor gene with nephrolithiasis in the Turkish population,” Urology Journal, vol. 13, no. 1, pp. 2509–2518, 2016. View at Google Scholar
  38. E. F. Remmers, F. Cosan, Y. Kirino et al., “Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease,” Nature Genetics, vol. 42, no. 8, pp. 698–702, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Kirino, G. Bertsias, Y. Ishigatsubo et al., “Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B51 and ERAP1,” Nature Genetics, vol. 45, no. 2, pp. 202–207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Hou, Z. Yang, L. Du et al., “Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study,” Arthritis & Rheumatism, vol. 64, no. 12, pp. 4104–4113, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Kılıç, F. Sılan, M. M. Hiz, S. Işık, Z. Ögretmen, and Ö. Özdemir, “Vitamin D receptor gene BSMI, FOKI, APAI, and TAQI polymorphisms and the risk of atopic dermatitis,” Journal of Investigational Allergology and Clinical Immunology, vol. 26, no. 2, pp. 106–110, 2016. View at Publisher · View at Google Scholar