The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer
Table 3
Ratios of mRNA levels to that of Nrf2 by percentage in colorectal cancer.
%
Keap1/Nrf2
Bach1/Nrf2
Hmox1/Nrf2
Normal tissue
107.1 (88.8–198.9)
100.0 (76.5–107.2)
105.1 (92.7–137.0)
Tumor
109.6 (102.3–146.0)
102.2 (95.2–116.0)
100.0 (84.4–136.5)
Distant metastasis
Normal tissue
With
108.6 (101.0–140.2)
100.0 (90.0–106.7)
106.3 (96.7–137.0)
Without
106.9 (88.8–198.9)
100.0 (76.5–107.3)
104.3 (92.7–135.8)
Tumor
With
109.1 (105.0–116.0)
102.2 (98.0–106.0)
97.4 (84.4–111.1)
Without
109.6 (102.0–146.0)
102.2 (95.0–116.0)
101.0 (92.7–136.5)
Significantly different between the tumor and normal tissues by Wilcoxon signed ranks test. Significantly different between tissues of subjects with or without distant metastasis by Mann–Whitney test.
