The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3′Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort

Table 3

Genotype frequencies of PARP-1 gene polymorphism in colorectal cancer and controls based on age.

Genotype	CRC	Controls	OR	(95% CI)	value	value	Corrected value
	Below 57
TT	59 (0.68)	50 (0.53)	Ref
TC	22 (0.25)	40 (0.42)	0.466	0.245–0.886	5.51	0.01890	0.0378
CC	6 (0.07)	5 (0.05)	1.017	0.293–3.532	0.00	0.97889	1
TC + CC	28 (0.32)	45 (0.47)	0.527	0.288–0.964	4.36	0.03682	0.07364
T	140 (0.80)	140 (0.74)	Ref
C	34 (0.20)	50 (0.26)	0.680	0.415–1.115	2.35	0.12537	0.25074
	Above 57
TT	52 (0.54)	40 (0.42)	Ref
TC	38 (0.40)	46 (0.48)	0.635	0.350–1.153	2.24	0.13471	0.26942
CC	6 (0.06)	9 (0.10)	0.513	0.169–1.560	1.42	0.23369	0.46738
TC + CC	44 (0.46)	55 (0.58)	0.615	0.347–1.090	2.78	0.09531	0.19062
T	142 (0.74)	126 (0.66)	Ref
C	50 (0.26)	64 (0.34)	0.693	0.446–1.077	2.66	0.10263	0.20526

Bonferroni corrected value.