Association between Vascular Endothelial Growth Factor Polymorphisms and Age-Related Macular Degeneration: An Updated Meta-Analysis

Table 1

Characteristics of the studies included in the meta-analysis.

Polymorphism	First author, year	Country	Ethnicity	Type of AMD	Genotype frequency in cases				Genotype frequency in controls
					Study size	11	12	22	Study size	11	12	22
rs833061	Richardson, 2007 [25]	Australia	Caucasian	Total AMD	566	154	259	153	157	40	78	39	0.937
				Dry AMD	100	27	43	30	157	40	78	39
				Wet AMD	336	92	158	86	157	40	78	39
	Lin, 2008 [20]	China	Asian	Total AMD	190	116	66	8	180	116	60	4	0.239
				Dry AMD	104	60	38	6	180	116	60	4
				Wet AMD	86	56	28	2	180	116	60	4
	Janik-Papis, 2009 [18]	Poland	Caucasian	Total AMD	265	48	191	26	134	60	63	11	0.323
				Dry AMD	88	13	67	8	134	60	63	11
				Wet AMD	177	35	124	18	134	60	63	11
	Szaflik, 2009 [26]	Poland	Caucasian	Wet AMD	100	14	78	8	104	37	56	11	0.129
	Qu, 2011 [27]	China	Asian	Wet AMD	159	81	58	20	140	81	50	9	0.733
	Cruz-González, 2013 [28]	Spain	Caucasian	Wet AMD	151	31	77	43	91	24	44	23	0.754
rs1413711	Almeida, 2012 [29]	Brazil	Mixed	Total AMD	160	65	66	29	140	67	65	8	0.127
				Dry AMD	36	14	14	8	140	67	65	8
				Wet AMD	124	51	52	21	140	67	65	8
	Churchill, 2006 [19]	UK	Caucasian	Wet AMD	45	17	18	10	94	19	54	21	0.147
	Lin, 2008 [20]	China	Asian	Total AMD	190	57	80	53	180	50	85	42	0.617
				Dry AMD	104	29	46	29	180	50	85	42
				Wet AMD	86	28	34	24	180	50	85	42
	Qu, 2011 [27]	China	Asian	Wet AMD	159	81	58	20	140	81	50	9	0.733
rs3025039	Galan, 2010 [30]	Finland	Caucasian	Total AMD	226	175	48	3	248	190	54	4	0.942
	Qu, 2011 [27]	China	Asian	Wet AMD	159	114	33	12	140	92	40	8	0.205
	Jiang, 2013 [31]	China	Asian	Total AMD	200	132	50	18	200	138	55	7	0.603
				Dry AMD	49	32	13	4	200	138	55	7
				Wet AMD	99	66	25	8	200	138	55	7
	Gonçalves, 2015 [32]	Brazil	Mixed	Wet AMD	88	69	19	0	95	76	19	0	0.279
	Tian, 2012 [33]	China	Asian	Total AMD	533	341	179	13	463	302	143	18	0.835
				Wet AMD	462	299	153	10	463	302	143	18
	Lin, 2008 [20]	China	Asian	Total AMD	190	120	58	12	180	134	42	4	0.742
				Dry AMD	104	75	27	2	180	134	42	4
				Wet AMD	86	45	31	10	180	134	42	4
rs2010963	Lin, 2008 [20]	China	Asian	Total AMD	190	40	132	18	180	34	116	30	<0.001
				Dry AMD	104	24	70	10	180	34	116	30
				Wet AMD	86	16	62	8	180	34	116	30
	Janik-Papis, 2009 [18]	Poland	Caucasian	Total AMD	265	164	84	17	134	85	44	5	0.813
				Dry AMD	88	47	30	11	134	85	44	5
	Qu, 2011 [27]	China	Asian	Wet AMD	159	54	70	35	140	39	74	27	0.442

value for Hardy Weinberg equilibrium in controls.