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Disease Markers
Volume 2016, Article ID 9085474, 9 pages
Research Article

Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification

1Endocrinology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico
2Cardiolology Department, San Juan de Dios General Hospital, Guatemala, Guatemala
3Molecular Biology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico

Received 17 October 2016; Accepted 7 December 2016

Academic Editor: Kailash Gulshan

Copyright © 2016 Esteban Jorge-Galarza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Insulin resistance is involved in the pathogenesis of cardiovascular disease, but its relationship with cardiovascular calcification has yielded conflicting results. The purpose of the present study was to investigate the role of hepatic and adipose tissue insulin resistance on the presence of coronary artery (CAC > 0) and aortic valve calcification (AVC > 0). Methods. In 1201 subjects (52% women, years old) without familiar and personal history of coronary heart disease, CAC and AVC were assessed by multidetector-computed tomography. Cardiovascular risk factors were documented and lipid profile, inflammation markers, glucose, insulin, and free fatty acids were measured. Hepatic insulin resistance (HOMA-IR) and adipose tissue insulin resistance (Adipo-IR) indices were calculated. Results. There was a significant relationship between HOMA-IR and Adipo-IR indices (, ). Participants in the highest quartiles of HOMA-IR and Adipo-IR indices had a more adverse cardiovascular profile and higher prevalence of CAC > 0 and AVC > 0. After full adjustment, subjects in the highest quartile of Adipo-IR index had higher odds of AVC > 0 (OR: 2.40; 95% CI: 1.30–4.43), as compared to those in the lowest quartile. Conclusions. Adipo-IR was independently associated with AVC > 0. This suggests that abnormal adipose tissue function favors insulin resistance that may promote the development and progression of AVC.