Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification

Table 5

Association of cardiovascular risk factors with aortic valve calcification presence (AVC > 0) in forward stepwise logistic regression analysis.

	Odds ratio (95% C.I.)	Probability
Age	1.14 (1.11–1.18)	<0.001
Gender	2.71 (1.85–3.98)	<0.001
Body mass index	1.04 (0.99–1.09)	0.069
Triglycerides	1.00 (0.99–1.00)	0.118
Current smoking	0.47 (0.28–0.78)	0.004
Use of statins	1.58 (0.90–2.76)	0.106
Estimated glomerular filtration rate	1.02 (0.99–1.05)	0.052
Low density lipoprotein cholesterol	1.01 (1.01–1.017)	<0.001
Type 2 diabetes	1.58 (1.01–2.47)	0.045
Adipo-IR quartile 1	1 (reference)
Adipo-IR quartile 2	1.53 (0.86–2.71)	0.142
Adipo-IR quartile 3	1.22 (0.68–2.21)	0.490
Adipo-IR quartile 4	2.33 (1.28–4.25)	0.006

Adipo-IR: adipose tissue insulin resistance.
Variables that drop out of the model: physical activity index, systolic blood pressure, diastolic blood pressure, high density lipoprotein cholesterol, homeostasis model assessment of insulin resistance (HOMA-IR), hs C-reactive protein, adiponectin, and visceral adipose tissue.