An Elevated Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Colorectal Cancer: A Meta-Analysis
Table 1
Baseline characteristics and design variables of eligible studies.
Study
Country
Year
Number of patients (M/F)a
Sampling time
Age: mean ± SD/ median (range)b
Cut-off point
Rate of PLR (n/N)c
Follow-up: mean ± SD/ median (range)d
Outcome measurede
NOSf
Mori
Japan
2015
152 (87/65)
Preoperative
Mean: 66.9; range: 35–89
150
84/152
Median: 20.5 (0.2–62.4)
OS, DFS
6
Song
Korea
2015
177 (83/94)
Before treatment
Median: 52 (25–81)
150
104/177
Median: 3.1 (0.1–33.3)
OS
5
Ozawa
Japan
2015
234 (142/92)
Preoperative
NR
25.4
53/234
Median: 64 (1–173)
OS, DFS, CSS
7
Neal
UK
2015
302 (192/110)
Preoperative
Median: 66 (26–85); mean: 64.8
150
169/302
Median: 29.7 (4–96)
OS, CSS
7
Li
China
2015
110 (58/52)
Preoperative
Mean: 62.9 ± 11.9
162
64/110
Max: 24
OS
6
Choi
Canada
2015
549 (296/253)
Preoperative
Median: 68.7 (28.3–92.6)
295
51/549
Median: 48 (0–124.8)
OS, RFS
8
Azab
USA
2014
580 (273/307)
Before treatment
Mean: 68.62 ± 12.82
147
387/580
Mean: 41.2; median: 40.5
OS, DFS, CSS
7
Neofytou
UK
2014
140 (88/52)
Preoperative
NR
150
58/140
Median: 33 (1–103)
OS, DFS
7
Ying
China
2014
205 (144/61)
Preoperative
NR
176
79/205
NR
OS, RFS, CSS
6
Szkandera
Austria
2014
372 (217/155)
Preoperative
Median: 64 (27–95)
RFS: 176 OS: 225
176 : 217/372; 225 : 164/372
Median: 68 (1–190)
OS, RFS
6
Sun
China
2014
255 (135/120)
Preoperative
Mean: 59.47 ± 12.63
150
120/254
NR
OS, DFS
6
Baranyai
Hungary
2014
CRC: 336 (180/156); mCRC: 118 (80/38)
Preoperative
CRC: 66.9 ± 11; mCRC: 61.0 ± 8.3
300
CRC: 31/336; mCRC: 5/118
Median: 36.1
OS, DFS
6
Son
Korea
2013
624 (368/256)
Preoperative
NR
300
16/624
Median: 42.0 (1–66)
OS, DFS
6
He
China
2013
243 (155/88)
Before chemotherapy
Median: 56 (18–83)
150
130/243
Median: 21.87
OS, DFS
7
Kwon
Korea
2012
200 (123/77)
Preoperative
Median: 64 (26–83)
150
83/200
Median: 33.6
OS
5
Carruthers
UK
2012
115 (75/40)
Pretreatment
Mean: 63.8; range: 32.3–81.1
160
NR
Median: 37.1
OS, RFS, DFS
5
Proctor
UK
2011
374
NR
NR
150
NR
Median: 51 (18–115)
OS, CSS
6
aM/F presents the number of males and females, respectively. bThe age of patients was summarized as mean with standard deviation or median with range. cThe rate of patients with elevated PLR. dThe follow-up period was summarized as mean with standard deviation or median with range. eThe outcomes assessed (OS, DFS, CSS, or/and RFS) were presented in each included study. fThe study quality was assessed with the Newcastle-Ottawa scale criteria. CRC: colorectal cancer; CSS: cancer-specific survival; DFS: disease-free survival; NOS: Newcastle-Ottawa scale criteria; NR: not reported; OS: overall survival; PLR: platelet-to-lymphocyte ratio; RFS: recurrence-free survival SD: standard deviation; UK: United Kingdom; USA: The United States of America.
