An Elevated Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Colorectal Cancer: A Meta-Analysis

Table 2

Results of subgroup analyses for prognostic significance of platelet-to-lymphocyte ratio.

	Overall survival	Disease-free survival	Cancer-specific survival	Recurrence-free survival
Overall	HR = 1.46 (1.23–1.73), I^2 = 60.8%	HR = 1.64 (1.17–2.30), I^2 = 73.5%	HR = 1.30 (1.12–1.50), I^2 = 0.0%	HR = 1.38 (1.09–1.74), I^2 = 20.7%
Sampling time
Preoperative	HR = 1.61 (1.28–2.02), I^2 = 61.4%	HR = 1.78 (1.12–2.83), I^2 = 77.3%	HR = 1.26 (1.04–1.52), I^2 = 33.3%	HR = 1.38 (1.09–1.74), I^2 = 20.7%
Metastatic status
M1	HR = 1.40 (1.23–1.60), I^2 = 26.6%	HR = 1.76 (1.23–2.51), I^2 = 0.0%	/	/
M0	HR = 1.63 (1.15–2.30), I^2 = 68.4%	HR = 1.82 (1.03–3.21), I^2 = 80.7%	HR = 1.75 (0.59–5.17), I^2 = 66.2%	HR = 1.38 (1.09–1.74), I^2 = 20.7%
Sample size
≥250	HR = 1.36 (1.01–1.83), I^2 = 77.3%	HR = 1.46 (0.80–2.64), I^2 = 85.3%	HR = 1.30 (1.11–1.52), I^2 = 0.0%	HR = 1.67 (1.21–2.29), I^2 = 0.0%
<250	HR = 1.53 (1.32–1.77), I^2 = 0.0%	HR = 1.76 (1.35–2.30), I^2 = 0.5%	HR = 1.75 (0.59–5.17), I^2 = 66.2%	HR = 1.11 (0.79–1.56), I^2 = 0.0%
Cut-off point
>150	HR = 1.60 (1.18–2.17), I^2 = 66.7%	HR = 2.03 (0.73–5.62), I^2 = 86.0%	HR = 1.22 (0.93–1.59), I^2 = 0.0%	HR = 1.38 (1.09–1.74), I^2 = 20.7%
≤150	HR = 1.33 (1.08–1.64), I^2 = 58.0%	HR = 1.49 (1.03–2.14), I^2 = 71.0%	HR = 1.34 (1.12–1.59), I^2 = 37.8%	/
Country
Asia	HR = 1.41 (1.22–1.63), I^2 = 45.2%	HR = 1.71 (0.97–3.01), I^2 = 73.9%	HR = 1.75 (0.59–5.17), I^2 = 66.2%	/
Europe & America	HR = 1.46 (1.11–1.91), I^2 = 71.9%	HR = 1.62 (0.99–2.65), I^2 = 79.0%	HR = 1.30 (1.11–1.52), I^2 = 0.0%	HR = 1.49 (1.11–2.00), I^2 = 35.2%
Study quality
≥6	HR = 1.44 (1.18–1.77), I^2 = 65.9%	HR = 1.72 (1.17–2.52), I^2 = 76.7%	HR = 1.30 (1.12–1.51), I^2 = 0.0%	HR = 1.46 (1.14–1.87), I^2 = 0.0%
<6	HR = 1.54 (1.23–1.93), I^2 = 0.0%	/	/	/
Study analysis type
Univariable type	HR = 1.63 (1.29–2.04), I^2 = 57.6%	HR = 2.08 (1.28–3.38), I^2 = 60.6%	HR = 1.31 (1.10–1.56), I^2 = 0.0%	HR = 1.23 (0.60–2.53), I^2 = 63.3%
Multivariable type	HR = 1.32 (1.03–1.69), I^2 = 59.9%	HR = 1.33 (0.91–1.93), I^2 = 66.6%	HR = 1.28 (0.99–1.66), I^2 = 32.7%	HR = 1.38 (1.03–1.85), I^2 = 5.3%

HR: hazard ratio; “/” symbol: no results due to insufficient studies.