Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer

Table 3

Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with disease-free survival (DFS).

Variable	Univariate analysis			Multivariate analysis
	HR	CI (95%)	value	HR	CI (95%)	value
Age
<65 years	1	—
≥65 years	0.616	0.384–1.002	0.543
Gender
Male	1	—
Female	1.065	0.665–1.707	0.793
AJCC stage
I and II	1	—		1	—
III and IV	0.393	0.243–0.635	<0.001	0.496	0.301–0.819	0.006
T stage					NR
T1 and T2	1	—
T3 and T4	0.348	0.140–0.864	0.023
Lymph node metastasis					NR
Negative	1	—
Positive	0.454	0.284–0.728	0.001
Distant metastasis					NR
M0	1	—
M1	0.139	0.073–0.266	<0.001
Differentiation
Well and moderate	1	—		1	—
Poor	0.478	0.297–0.772	0.003	0.577	0.352–0.945	0.029
GRK3 expression
Negative	1	—		1	—
Weak and strong	0.390	0.209–0.727	0.003	0.453	0.241–0.854	0.014

HR: hazard radio; CI: confidence interval; NR: variable was not included in the resultant model. Significance indicated that the 95% CI of HR was not including 1.