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Disease Markers
Volume 2017, Article ID 1372387, 8 pages
Research Article

Expression of Autophagy-Related Proteins in Hürthle Cell Neoplasm Is Different from That in Follicular Neoplasm

Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea

Correspondence should be addressed to Ja Seung Koo; ca.shuy@6791sjk

Received 22 February 2017; Revised 23 June 2017; Accepted 5 July 2017; Published 27 July 2017

Academic Editor: Stamatios E. Theocharis

Copyright © 2017 Yoon Jin Cha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. We aimed to evaluate expression of autophagy-related proteins in Hürthle cell neoplasm (HCN) and follicular neoplasm (FN) and assess the clinical implications. Methods. 265 FNs (112 follicular carcinomas and 153 follicular adenomas) and 108 HCNs (27 Hürthle cell carcinomas and 81 Hürthle cell adenomas) were made into a tissue microarray. Immunohistochemical staining and Western blot for autophagy-related proteins (beclin-1, light chain (LC) 3A, LC3B, p62, and BNIP3) were performed, and the results were statistically analyzed. Results. A higher expression rate of beclin-1, LC3B, p62, and BNIP3 was found in HCN than in FN (). The expression rate of beclin-1, LC3B, p62, and BNIP3 was the highest in HCCs followed by HCAs, FCs, and FAs in that order (). HCCs were positive for the largest number of autophagy-related proteins followed by HCAs, FCs, and FAs (), and most of the positive markers identified in HCCs were the high autophagy type (), defined by positive staining for three or more of the five autophagy-related proteins. Conclusion. The autophagy-related proteins, beclin-1, LC3A, LC3B, p62, and BNIP3, were more frequently expressed in HCNs than in FNs, and HCCs showed the highest expression rate.