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Disease Markers
Volume 2017, Article ID 1754696, 8 pages
Research Article

Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation

1Department of Hepatobiliary Pancreatic Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Department of General Surgery, Hainan Cancer Hospital, Haikou, China

Correspondence should be addressed to Junwei Fan; moc.361@103088wjnaf and Zhihai Peng; moc.361@8591hzgnep

Received 2 June 2017; Revised 20 August 2017; Accepted 14 September 2017; Published 15 October 2017

Academic Editor: Yi-Chia Huang

Copyright © 2017 Tao Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the association of donor and recipient IL-15 genetic variants with HCC recurrence and prognosis after LT. Methods. A total of 112 liver transplant patients with HBV-related HCC were enrolled. IL-15 rs10519613 and rs13122930 were genotyped in donors and recipients. Results. Recipient IL-15 rs10519613 polymorphism was found to be significantly related to HCC recurrence after LT. In multivariate analysis, tumor thrombus, UCSF criteria, and recipient IL-15 rs10519613 genotypes were independent predictive factors of HCC recurrence after LT. Kaplan-Meier survival analysis demonstrated that patients with recipient IL-15 rs10519613 CA/AA genotypes had a decreased disease-free survival and overall survival than those with the CC genotype. Recipient IL-15 rs10519613 genetic variant could improve survival prediction when combined with the UCSF criteria. Furthermore, Cox proportional hazard regression analysis revealed that tumor size (, ), tumor thrombus (, ), UCSF criteria (, ), and recipient IL-15 rs10519613 genotype (, ) were independent factors of predicting DFS and OS. Conclusions. Recipient IL-15 rs10519613 polymorphism was associated with HCC recurrence after LT and might be a potential genetic marker for the clinical outcome of HCC patients treated with LT.