Zonulin: A Potential Marker of Intestine Injury in Newborns

Table 1

Demographic and clinical characteristics of the study group () with distribution according to clinical diagnosis—median values and 1–3 quartiles.

	Control group	Sepsis group	ELGAN group	NEC group	Rotavirus group	AWD group
N	14	12	24	12	16	3
Gender (F/M)	6/8	2/10	8/16	8/4	5/11	2/1
Birth weight (g)	3260 (2850–3440)	3208 (2505–3465)	1120 (800–1400)	1955 (1100–2470)	3000 (2495–3690)	2250 (2100–2700)
Body weight (g)	3260 (2850–3400)	3208 (2505–3465)	1120 (800–1400)	1962 (1115–2585)	3302 (2790–3805)	2270 (2190–2610)
1’Apgar (pts)	9 (8–10)	9 (7–10)	5 (3–6)	6 (5–8)	10 (8–10)	6 (2–8)
5’Apgar (pts)	10 (9-10)	10 (7–10)	5 (4–7)	8 (7-8)	10 (9-10)	7 (7-8)
GA (wks)	39 (37–39)	38 (36–40)	28 (25–31)	33 (29–36)	38 (36–39)	37 (36–38)
DOL	5 (2–11)	10 (3–18)	2 (1–5)	7 (4–25)	24 (17–27)	3 (2–5)
MOD (SD/CS)	9/5	8/4	6/18	3/9	7/9	0/3
Zonulin (ng/ml)	3.5 (2.7–4.8)	3.5 (2.8–4.3)	3.8 (2.0–5.4)	8.6 (3.8–11.9)	36.0 (26.0–43.2)	20.3 (17.7–28.2)
NTISS (pts)	3 (2–5)	18 (13–26)	24 (21–26)	23 (18–25)	8 (7–9)	21 (19–23)
CRP (mg/dl)	0.2 (0.2–1.6)	52.1 (15.8–94.1)	3.1 (0.9–9.5)	22.8 (6.1–59.1)	0.7 (0.2–2.1)	47.5 (1.9–58.2)
PCT (ng/ml)	0.1 (0.1–0.2)	9.0 (2.2–14.2)	5.7 (2.7–10.6)	2.2 (0.7–12.0)	0.1 (0.1–0.3)	2.1 (0.9–3.3)
WBC (1000/μl)	11.7 (9.9–13.0)	10.8 (5.7–21.0)	16.6 (9.6–23.1)	13.3 (11.3–19.8)	10.8 (8.1–115)	10.3 (7.6–24.2)
PLT (1000/μl)	277 (185–322)	174 (86–258)	133 (92–187)	226 (166–359)	386 (310–484)	230 (213–263)

ELGAN: extremely low gestational age newborn; NEC: necrotizing enterocolitis; AWD: abdominal wall defect; N: number; F: female; M: male; g: grams; pts: points; GA: gestational age; wks: weeks; DOL: day of life; MOD: mode of delivery; SD: spontaneous delivery; CS: cesarean section. Statistical significance versus control group. ; ; .