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Disease Markers
Volume 2017 (2017), Article ID 2543059, 7 pages
https://doi.org/10.1155/2017/2543059
Research Article

CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population

1Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China
2Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China
3Department of Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China
4Department of Urology, North Hospital, CHU of Saint-Etienne, 42055 Saint-Etienne, France

Correspondence should be addressed to Chun Pu

Received 14 January 2017; Revised 27 March 2017; Accepted 23 April 2017; Published 24 May 2017

Academic Editor: Tilman Todenhöfer

Copyright © 2017 Gang Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. CD146 is a membrane signal receptor in tumor-induced angiogenesis. However, limited studies have focused on the CD146 promoter polymorphisms in clear cell renal cell carcinoma (ccRCC). Purpose. The purpose of this study was to investigate the association between polymorphisms located in the promoter region of the CD146 gene and characteristics of ccRCC in Chinese population. The association between the CD146 promoter polymorphisms and CD146 expression was also investigated in ccRCC. Materials and Methods. A total of 600 samples including 300 ccRCC patients and 300 healthy controls were collected for analysis of the CD146 promoter polymorphisms by direct sequence. The CD146 expressions were measured by qRT-PCR. Results. We had not found any significant differences in genotypic and allelic frequencies of CD146 promoter polymorphisms between ccRCC patients and controls. The rs3923594 was associated with stage and metastasis (300 cases) and recurrence (263 cases) of ccRCC in Chinese population. A significant association was also observed between the rs3923594 and CD146 expression (227 cases) in ccRCC. Conclusions. CD146 promoter polymorphisms were not associated with the risk of ccRCC in Chinese population. The rs3923594 was an independent predictor of recurrence in Chinese patients with localized ccRCC.