Research Article
Diagnostic Value of the Methylation of Multiple Gene Promoters in Serum in Hepatitis B Virus-Related Hepatocellular Carcinoma
Table 2
The positive rates of methylation for promoters of 6 genes in serum [n (%)].
| | Gene | HCC patients () | LC patients () | CHB patients () | Healthy controls () | χ2a | a | χ2b | b |
| | RASSF1A | 51 (52.04) | 10 (13.33) | 4 (4.44) | 3 (3.75) | 26.215 | 0.000 | 49.078 | 0.000 | | APC | 36 (36.73) | 4 (5.33) | 2 (2.22) | 0 (0) | 21.834 | 0.000 | 32.543 | 0.000 | | BVES | 29 (29.59) | 3 (4.00) | 1 (1.11) | 0 (0) | 16.799 | 0.000 | 26.292 | 0.000 | | TIMP3 | 11 (11.22) | 2 (2.67) | 0 (0) | 0 (0) | 4.477 | 0.034 | 10.730 | 0.001 | | GSTP1 | 17 (17.35) | 2 (2.67) | 0 (0) | 0 (0) | 9.365 | 0.002 | 17.164 | 0.000 | | HOXA9 | 20 (20.41) | 4 (5.33) | 3 (3.33) | 0 (0) | 8.081 | 0.004 | 10.863 | 0.001 |
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HCC: hepatocellular carcinoma; LC: liver cirrhosis; CHB: chronic hepatitis B. aHCC patients versus LC patients, . bHCC patients versus CHB patients, .
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