Diagnostic Value of the Methylation of Multiple Gene Promoters in Serum in Hepatitis B Virus-Related Hepatocellular Carcinoma

Table 3

Powers of the methylation statuses of multiple genes and the AFP assay for distinguishing HCC from CHB.

Indicator	Sensitivity (%)	Specificity (%)	AUC
RASSF1A	52.0	91.5	0.718
APC	36.7	96.4	0.650
BVES	29.6	97.6	0.636
TIMP3	11.2	98.8	0.356
GSTP1	17.4	98.7	0.486
HOXA9	20.4	95.8	0.521
AFP (≥20 ng/l)	48.0	73.9	0.609

HCC: hepatocellular carcinoma; CHB: chronic hepatitis B; AUC: area under the curve.