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Disease Markers
Volume 2017, Article ID 3104180, 5 pages
Research Article

A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia

1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China
2Department of Pharmacy, Stomatology Hospital, Jilin University, Changchun 130041, China
3Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
4VA Medical Center, VA Connecticut Healthcare System, West Haven, CT, USA

Correspondence should be addressed to Qiong Yu; nc.ude.ulj@gnoiquy

Received 15 October 2016; Accepted 27 December 2016; Published 19 January 2017

Academic Editor: Hubertus Himmerich

Copyright © 2017 Wenwang Rao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia. 1,145 patients with schizophrenia and 1,016 healthy volunteers from the Han population in Northeast China were recruited. The association of three tag single nucleotide polymorphisms (SNPs) (rs2070011 in the UTR, rs2070016 in intron 4, and rs2070022 in the UTR) in FGA and schizophrenia was examined using a case-control study design. Genotypic distributions of these three SNPs were not found to be significantly different between cases and controls (rs2070011: , ; rs2070016: , ; rs2070022: , ). There were also no significant differences in SNP allelic frequencies between cases and controls (all ). Additionally, the frequency of haplotypes consisting of alleles of these three SNPs was not significantly different between cases and healthy control subjects (global , ). Our study did not show a significant association of FGA SNPs with schizophrenia. Future studies may need to test more FGA SNPs in a larger sample to identify those SNPs with a minor or moderate effect on schizophrenia.