Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population

Table 4

Associations between IL-31 SNPs and DCM patients’ characteristics.

	Genotype	rs4758680				Genotype	rs7977932
		LVEF <30%; n (%)	LVEF ≥30%; n (%)	OR (95%CI)	value		LVEF <30%; n (%)	LVEF ≥30%; n (%)	OR (95%CI)	value
Model
Codominant	CC	131 (85.1%)	144 (81.4%)	1.00	—	CC	128 (83.1%)	143 (80.8%)	1.00	—
	CA	14 (9.1%)	29 (16.4%)	0.52 (0.26–1.03)	0.035	CG	24 (15.6%)	32 (18.1%)	1.20 (0.67–2.15)	0.810
	AA	9 (5.8%)	4 (2.3%)	2.56 (0.76–8.33)	—	GG	2 (1.3%)	2 (1.1%)	0.82 (0.11–5.97)	—
Dominant	CC	131 (85.1%)	144 (81.4%)	1.00	—	CC	128 (83.1%)	143 (80.8%)	1.00	—
	CA/AA	23 (14.9%)	33 (18.6%)	0.76 (0.42–1.37)	0.360	CG/GG	26 (16.9%)	34 (19.2%)	1.17 (0.66–2.07)	0.590
Recessive	CC/CA	145 (94.2%)	173 (97.7%)	1.00	—	CC/CG	152 (98.7%)	175 (98.9%)	1.00	—
	AA	9 (5.8%)	4 (2.3%)	2.78 (0.84–9.09)	0.081	GG	2 (1.3%)	2 (1.1%)	0.79 (0.11–5.75)	0.820
Overdominant	CC/AA	140 (90.9%)	148 (83.6%)	1.00	—	CC/GG	130 (84.4%)	145 (81.9%)	1.00	—
	CA	14 (9.1%)	29 (16.4%)	0.50 (0.25–0.99)	0.042	CG	24 (15.6%)	32 (18.1%)	1.20 (0.67–2.16)	0.530
	Allele					Allele
	C	276 (90.0%)	317 (90.0%)	1.00	—	C	280 (91.0%)	318 (90.0%)	1.00	—
	A	32 (10.0%)	37 (10.0%)	1.00 (0.64–1.56)	0.99	G	28 (9.0%)	36 (10.0%)	1.12 (0.67–1.88)	0.670

LVEF: left ventricular ejection fraction; OR: odds ratio; CI: confidence interval; SNP analysis adjusted for age and gender.