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Disease Markers
Volume 2017, Article ID 4590235, 8 pages
https://doi.org/10.1155/2017/4590235
Research Article

Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population

1Department of Laboratory Medicine, The People’s Hospital of Guangxi Autonomous Region, Nanning, China
2Department of Pharmacy, The People’s Hospital of Guangxi Autonomous Region, Nanning, China
3Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, China
4Department of Neurology, The First Hospital of Changsha, Changsha, China
5Department of Clinical Laboratory, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China
6Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China

Correspondence should be addressed to Qi-le Gao; moc.361@8699lqoag

Received 6 October 2017; Accepted 10 December 2017; Published 21 December 2017

Academic Editor: Juan Bueno

Copyright © 2017 Ying Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate the association of single-nucleotide polymorphisms (SNPs) in SP110 gene and TNF-α gene among pulmonary TB (PTB) and spinal TB (STB) patients. Methods. In a total of 190 PTB patients, 183 STB patients were enrolled as the case group and 362 healthy individuals at the same geographical region as the control group. The SP110 SNPs (rs722555 and rs1135791) and the promoter -308G>A (rs1800629) and -238G>A (rs361525) polymorphisms in TNF-α were genotyped. Results. TNF-α -238G>A polymorphism was involved in susceptibility to STB, but not to PTB. The TNF-α -238 A allele was a protective factor against STB (A versus G: OR [95% CI] = 0.331 [0.113–0.972], ). Furthermore, the presence of the -238 A allele was considered a trend to decrease the risk of STB (AG versus GG: , OR [95% CI] = 0.352 [0.118–1.053]; AA + AG versus GG: , OR [95CI%] = 0.335 [0.113–0.999]). However, SP110 SNPs (rs722555 and rs1135791) and TNF-α -308G>A (rs1800629) showed no association with PTB and STB in all genetic models. Conclusion. The TNF-α -238 A allele appeared a protective effect against STB, whereas the SP110 SNPs (rs722555 and rs1135791) and TNF-α -308G>A (rs1800629) showed no association with susceptibility to PTB and STB patients in southern China.