Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis
Table 3
Univariate analysis for prognostic factors of gastric cancer.
Characteristic
Patient
Death (%)
Mean (months)
Age (year)
≤45 years
65
29 (44.6)
54.01
0.935
>45 years
670
287 (42.8)
57.42
Gender
Male
539
237 (44.0)
56.55
0.343
Female
196
79 (40.3)
59.35
Tumor size
<5 cm
422
144 (34.1)
64.89
<0.001
≥5 cm
302
165 (54.6)
47.22
Histological grade
low grade
309
118 (38.2)
61.85
0.006
high grade
373
177 (47.5)
52.74
WHO classification
Tubular
569
238 (41.8)
58.55
0.167
Signet-ring cell
36
18 (50.0)
50.57
Others
130
60 (46.2)
45.23
Vascular invasion
Negative
217
39 (18.0)
76.06
<0.001
Positive
506
270 (53.4)
49.61
Neural invasion
Negative
330
97 (29.4)
68.19
<0.001
Positive
393
212 (53.9)
48.43
Depth of invasion
T1/T2
198
26 (13.1)
80.23
<0.001
T3/T4
515
278 (54.0)
49.00
Lymph metastasis
N0
214
33 (15.4)
76.15
<0.001
N1/N2/N3
501
271 (54.1)
48.79
TNM stage
I
136
12 (8.8)
81.13
<0.001
II
278
86 (30.9)
67.90
III
312
212 (67.9)
36.55
Chemotherapy
None
486
200 (41.2)
57.68
0.056
FOLFOX-4
137
66 (48.2)
52.37
XELOX
74
26 (35.1)
62.25
Others
38
24 (63.2)
42.63
Rs213210
T/T
159
67 (42.1)
54.24
0.949
C/C+C/T
566
245 (43.3)
57.14
Rs2505901
T/T
476
204 (42.9)
57.52
0.710
C/T-C/C
258
112 (43.4)
56.11
Rs4938723
T/T
330
148 (44.8)
65.71
0.440
C/C-C/T
401
166 (41.4)
73.50
Rs11134527
A/A
276
134 (48.5)
52.93
0.016
A/G-G/G
456
180 (39.5)
60.01
most characteristics, less than half patients were dead, so mean overall survival (OS) time was presented for most of the median OS that could not be calculated. values were computed by the log-rank test.