Research Article

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Table 3

Univariate analysis for prognostic factors of gastric cancer.

CharacteristicPatient Death (%)Mean (months)

Age (year)
 ≤45 years6529 (44.6)54.010.935
 >45 years670287 (42.8)57.42
Gender
 Male539237 (44.0)56.550.343
 Female19679 (40.3)59.35
Tumor size
 <5 cm422144 (34.1)64.89<0.001
 ≥5 cm302165 (54.6)47.22
Histological grade
 low grade309118 (38.2)61.850.006
 high grade373177 (47.5)52.74
WHO classification
 Tubular569238 (41.8)58.550.167
 Signet-ring cell3618 (50.0)50.57
 Others13060 (46.2)45.23
Vascular invasion
 Negative21739 (18.0)76.06<0.001
 Positive506270 (53.4)49.61
Neural invasion
 Negative33097 (29.4)68.19<0.001
 Positive393212 (53.9)48.43
Depth of invasion
 T1/T219826 (13.1)80.23<0.001
 T3/T4515278 (54.0)49.00
Lymph metastasis
 N021433 (15.4)76.15<0.001
 N1/N2/N3501271 (54.1)48.79
TNM stage
 I13612 (8.8)81.13<0.001
 II27886 (30.9)67.90
 III312212 (67.9)36.55
Chemotherapy
 None486200 (41.2)57.680.056
 FOLFOX-413766 (48.2)52.37
 XELOX7426 (35.1)62.25
 Others3824 (63.2)42.63
Rs213210
 T/T15967 (42.1)54.240.949
 C/C+C/T566245 (43.3)57.14
Rs2505901
 T/T476204 (42.9)57.520.710
 C/T-C/C258112 (43.4)56.11
Rs4938723
 T/T330148 (44.8)65.710.440
 C/C-C/T401166 (41.4)73.50
Rs11134527
 A/A276134 (48.5)52.930.016
 A/G-G/G456180 (39.5)60.01

most characteristics, less than half patients were dead, so mean overall survival (OS) time was presented for most of the median OS that could not be calculated. values were computed by the log-rank test.