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Disease Markers
Volume 2017, Article ID 5189803, 9 pages
https://doi.org/10.1155/2017/5189803
Review Article

Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer?

Huzhou Central Hospital, No. 198 Hongqi Road, Huzhou, Zhejiang 313000, China

Correspondence should be addressed to Pan Yuefen; moc.361@352366nefeuynap

Received 11 January 2017; Accepted 14 February 2017; Published 16 March 2017

Academic Editor: Hong C. Jin

Copyright © 2017 Han Shuwen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Colorectal cancer (CRC) was one of the most frequent cancers worldwide. Accurate risk and prognosis evaluation could obtain better quality of life and longer survival time for the patients. Current research hotspot was focus on the gene biomarker to evaluate the risk and prognosis. Mitochondrion contains its own DNA and regulates self-replicating so that it can be as a candidate biomarker for evaluating the risk and prognosis of colorectal cancer. But there were already huge controversies on this issue. The review was to summarize current viewpoints of the controversial issues and described our understanding from the four aspects including mtDNA copy number, mitochondrial displacement loop, mtDNA variation, and mtDNA microsatellite instability, wishing the summary of the mtDNA in colorectal cancer could provide a meaningful reference or a valuable direction in the future studies.