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Disease Markers
Volume 2017, Article ID 5241012, 7 pages
Research Article

Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients

1Department of Internal Medicine, Division of Rheumatology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, Romania
2Division of Rheumatology, Timişoara, Romania
3Department of Internal Medicine, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, Romania
4Department of Pathophysiology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, Romania
5University of Medicine and Pharmacy “Victor Babeş”, Timişoara, Romania

Correspondence should be addressed to Alexandru Caraba; moc.oohay@abaracxela

Received 29 June 2017; Revised 16 September 2017; Accepted 28 September 2017; Published 22 October 2017

Academic Editor: Zhongjie Shi

Copyright © 2017 Alexandru Caraba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction. Statistical analysis were performed using the Student’s t-test and the Pearson’s test. p values of less than 0.05 were considered statistically significant. Results. The group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (). Significant inverse correlations between the levels of 25(OH) vitamin D and DAS28, respective insulin resistance, and significant positive correlation between 25(OH) vitamin D and endothelial function were demonstrated. Conclusion. In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction.