Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis

Figure 2

Serum GDF-15 levels in critically ill patients are associated with organ failure and disease severity. Serum levels of GDF-15 at the time of admission to the ICU were significantly higher in critically ill patients with renal failure (cystatin C-based glomerular filtration rate (GFR) < 50 mL/min (a)); asterisks denote significance values at) and hepatic failure (prothrombin time < 50% (b)). Critically ill patients with higher disease severity as represented by clinical scores (APACHE II (c) and SOFA (d)) showed significantly higher GDF-15 levels.

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