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Disease Markers
Volume 2017 (2017), Article ID 5434310, 5 pages
Research Article

Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis

1Department of Neurology, Saarland University Medical Center, Homburg, Germany
2Department of Translational Medicine, Section of Neurology, University of Piemonte Orientale, Novara, Italy
3Division of Neurology, “Franz Tappeiner” Hospital, Merano, Italy
4Department of Neurology, Christian Doppler Medical Centre, Paracelsus Medical University Salzburg, Salzburg, Austria
5Department of Neurology, “Annunziata” Hospital, Cosenza, Italy
6Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

Correspondence should be addressed to Piergiorgio Lochner

Received 25 June 2017; Accepted 17 August 2017; Published 11 September 2017

Academic Editor: Patrizia Cardelli

Copyright © 2017 Piergiorgio Lochner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Objective. To investigate the relationship between optic nerve sheath diameter, optic nerve diameter, visual acuity and osteopontin, and neurofilament heavy chain in patients with acute optic neuritis. Patients and Methods. Sonographic and visual acuity assessment and biomarker measurements were executed in 23 patients with unilateral optic neuritis and in 19 sex- and age-matched healthy controls. Results. ONSD was thicker on the affected side at symptom onset (median 6.3 mm; interquartile range 6.0–6.5) than after 12 months (5.3 mm; 4.9–5.6; ) or than in controls (5.2 mm; 4.8–5.5; ). OND was significantly increased in the affected side (3.4 mm; 2.9–3.8) compared to healthy controls (2.7 mm; 2.5–2.9; ) and was thicker at baseline than after 12 months (2.8 mm; 2.7–3.0; ). Visual acuity improved significantly after 12 months (1.00; 0.90–1.00) compared to onset of symptoms (0.80; 0.40–1.00; ). OPN levels were significantly higher in patients at presentation (median 6.44 ng/ml; 2.05–10.06) compared to healthy controls (3.21 ng/ml, 1.34–4.34; ). Concentrations of NfH were significantly higher in patients than in controls. Conclusion. ONSD and OND are increased in the affected eye. OPN and NfH are elevated in patients, confirming the presence of any underlying inflammation and axonal injury.