Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?

Table 3

Frequency of MMP-9 (–1562 C/T) genotype in the patients with pituitary adenoma (PA) and in the control group by gender.

Gene marker	Genotype/allele	Frequency (%)
		Control group; (%)		HWE	value	PA group; (%)		HWE	value
		Females	Males			Females	Males
MMP-9 (–1562) Rs3918242	Genotype
	C/C	204 (64.6)^1	136 (64.8)	0.991	0.868	44 (81.5)^1	26 (81.2)	0.836	1.00
	C/T	10 (32.3)^2	67(31.9)^3		0.928	8(14.8)^2	4 (12.5)^3		1.00
	T/T	10 (3.2)	7 (3.3)		0.915	2 (3.7)	2 (6.2)		0.626
	Total	316 (100)	210 (100)			54 (100)	32 (100)
	Allele
	C	510 (80.7)	339 (80.71)			96 (88.89)	56 (87.5)
	T	122 (19.3)	81 (19.29)			12 (11.11)	8 (12.5)

MMP, matrix metalloproteinase; value, significance level (alpha = 0.05); value HWE, significance level (alpha = 0.05) by Hardy-Weinberg equilibrium.
0.018.
0.01.
0.023.