Does MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?

Table 7

Frequency of MMP-9 (–1562 C/T) genotype in the patients with pituitary adenoma (PA) and in the control group by PA recurrences.

Gene marker	Genotype/allele	Frequency (%)
		Control group; (%); ()	HWE	Nonrecurrence PA group; (%); ()	HWE	Recurrence PA group; (%); ()	HWE
MMP-9 (–1562) Rs3918242	Genotype
	C/C	340 (64.6)^1	0.469	54 (81.8)^1	0.103	16 (80.0)	0.007
	C/T	169 (32.1)^2,3		10 (15.2)^2		2 (10.0)^3
	T/T	17 (3.2)		2 (3.0)
	Total	526 (100)		66 (100)		2 (10.0)
	Allele					20 (100)
	C	849 (80.70)		118 (89.39)		34 (85.0)
	T	203 (19.30)		14 (10.61)		6 (15.0)

MMP, matrix metalloproteinase; value, significance level (alpha = 0.05); value HWE, significance level (alpha = 0.05) by Hardy-Weinberg equilibrium.
= 0.005.
= 0.004.
= 0.047.