CACNA1B (Ca_v2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer

Table 2

Univariate and multivariate analysis of prognostic factors in CACNA1B (2.2) for 5-year overall survival.

Characteristic	Univariate analysis			Multivariate analysis
	HR		95% CI	HR		95% CI
CACNA1B (2.2) expression
High versus low	2.701	<0.001	1.797 4.061	2.639	<0.001	1.699 4.099
Gender
Male versus female	1.530	0.020	1.070 2.188	1.230	0.339	0.804 1.882
Age (years)
≤60 versus >60	1.273	0.189	0.888 1.826
Tumor size (cm)
≤3 versus >3	2.064	<0.001	1.431 2.976	1.138	0.597	0.705 1.836
Histopathology grading
Adenocarcinoma versus squamous cell carcinoma versus others	0.419	<0.001	0.306 0.574	0.572	0.004	0.392 0.837
Lymph node metastasis
No metastasis versus metastasis	1.482	0.047	1.005 2.185	0.995	0.985	0.575 1.721
Smoking
No smoking versus smoking	2.237	0.001	1.365 3.666	2.526	0.001	1.440 4.430
TNM stage
Stage I versus stage II versus stage III	1.425	0.006	1.108 1.833	1.349	0.147	0.900 2.024

; others, adenosquamous carcinoma.