Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population
Table 3
Genotype distribution and allele frequencies of MMP-1 (-519A/G; -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 (-181A/G), and MMP-12 (-82A/G) polymorphisms among nonobese and obese subjects.
SNP
Genotypes and alleles
Nonobese£ (, %)
Obese£ (, %)
Adjusted OR (95% CI)
MMP-1 (-519A/G)
rs1144393
AA n (%)
106 (53)
65 (39.6)
1
AG n (%)
83 (41.5)
85 (51.8)
1.57 (1.02–2.41)
0.03
GG n (%)
11 (5.5)
14 (8.6)
1.95 (0.84–4.55)
0.12
AG+GG n (%)
94 (47)
99 (60.4)
1.61 (1.07–2.44)
0.02
A n (%)
295 (73.75)
215 (65.55)
1
G n (%)
105 (26.25)
113 (34.45)
1.47 (1.07–2.03)
0.02
MMP-1 (-1607 1G/2G)
rs1799750
1G1G n (%)
24 (12)
22 (13.4)
1
1G2G n (%)
75 (37.7)
62 (37.8)
0.88 (0.47–1.63)
0.68
2G2G n (%)
100 (50.3)
80 (48.8)
0.9 (0.45–1.73)
0.73
1G2G+2G2G n (%)
175 (88)
142 (86.6)
0.87 (0.45–1.67)
0.68
1G n (%)
123 (30.9)
106 (32.32)
1
2G n (%)
275 (69.1)
222 (67.68)
0.93 (0.68–1.28)
0.7
MMP-3 Lys45Glu (A/G)
rs679620
AA n (%)
69 (34.2)
33 (20.1)
1
AG n (%)
100 (49.5)
93 (56.7)
1.92 (1.16–3.18)
0.01
GG n (%)
33 (16.3)
38 (23.2)
2.4 (1.30–4.5)
0.006
AG+GG n (%)
133 (65.8)
131 (79.9)
2.04 (1.26–3.3)
0.004
A n (%)
238 (58.91)
159 (48.48)
1
G n (%)
166 (41.09)
169 (51.52)
1.52 (1.13–2.04)
0.004
MMP-7 (-181A/G)
rs11568818
AA n (%)
53 (26.2)
38 (23)
1
AG n (%)
103 (51)
91 (55.2)
1.23 (0.74–2.03)
0.41
GG n (%)
46 (22.8)
36 (21.8)
1.09 (0.60–1.99)
0.77
AG+GG n (%)
149 (73.8)
127 (77)
1.19 (0.73–1.92)
0.48
A n (%)
209 (51.73)
167 (50.61)
1
G n (%)
195 (48.27)
163 (49.39)
1.04 (0.78–1.4)
0.76
MMP-12 (-82A/G)
rs2276109
AA n (%)
178 (88.6)
126 (76.4)
1
AG n (%)
23 (11.4)
38 (23)
2.33 (1.32–4.11)
0.003
GG n (%)
0
1 (0.6)
2.28
0.99
AG+GG n (%)
23 (11.4)
39 (23.6)
2.39 (1.36–4.2)
0.002
A n (%)
379 (94.28)
290 (87.88)
1
G n (%)
23 (5.72)
40 (12.12)
2.27 (1.33–3.88)
0.002
The chi-square (χ2) test was used for the determination of genotype distribution between nonobese and obese subjects. Adjustments for age and sex were performed by logistic regression analysis. CI: confidence interval; OR: odds ratio. values remained significant after the Bonferroni correction. £The sum does not add up to the total because of a few missing genotypes in nonobese and obese subjects.
