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Disease Markers
Volume 2017, Article ID 6359603, 8 pages
https://doi.org/10.1155/2017/6359603
Research Article

FOXP3 Allelic Variants and Haplotype Structures Are Associated with Aggressive Breast Cancer Subtypes

1Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Celso Garcia Cid Highway, Pr 445 Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil
2Department of General Biology, Biological Sciences Center, State University of Londrina, Celso Garcia Cid Highway, Pr 445 Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil
3Department of Pathology, Clinical and Toxicological Analysis, Health Science Center, State University of Londrina, Celso Garcia Cid Highway, Pr 445 Km 380, Campus Universitário, 86057-970 Londrina, PR, Brazil

Correspondence should be addressed to Maria Angelica Ehara Watanabe; moc.liamg@leutaweam

Received 5 April 2017; Accepted 24 May 2017; Published 21 June 2017

Academic Editor: Leigh A. Madden

Copyright © 2017 Bruna Karina Banin Hirata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

FOXP3 genetic polymorphisms have been associated with cancer development and prognosis. In this context, the present study aimed to evaluate the g.10403A>G (rs2232365) polymorphisms and g.8048A>C (rs3761548), in aggressive breast cancer (BC) subtypes, including, Luminal B HER2+ (LB), HER2-enriched (HER2+), and triple-negative (TN). Polymerase chain reaction followed by enzymatic restriction was performed to genotyping 117 BC samples and 300 controls. A significant association of AA genotype (g.10403A>G) in relation to BC susceptibility (OR = 1.93; 95% CI = 1.01–3.66; ) was observed. The GG (g.10403A>G) genotype was correlated with higher proliferation index (Ki-67) in HER2+ subtype (τ = 0.47; ) and advanced TNM staging in TN (τ = 0.23; ). A correlation of AA genotype (g.8048A>C) with higher Ki-67 (τ = −0.47; ) and lower histological grade (τ = 0.39; ) in HER2+ was also found. GA haplotype was correlated with lower histological grade (τ = −0.15; ) and higher Ki-67 (τ = 0.43; ) in HER2+ and advanced staging in TN (τ = 0.29; ). On the other hand, AC haplotype was correlated with lower Ki-67 (τ = −0.54; ) and staging (τ = −0.29; ) in HER2+ and TN respectively. Results showed that FOXP3 influence regarding clinical outcome depends greatly on the BC subtype and indicated this transcription factor as a promising marker in aggressive BC subtypes.