Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease

Figure 2

Association of hematological, biochemical, and immunological biomarkers in children with HbSC, using elevated TAMMV as defined by Deane and colleagues (2007). (a) Children with HbSC with TAMMV ≥ 128 cm/s have low RDW ( value calculated using Mann–Whitney). The mean and standard deviation were 15.94 ± 1.34% in children with TAMMV < 128 cm/s and 15.26 ± 0.9% in children with TAMMV ≥ 128 cm/s. (b) Children with HbSC with TAMMV ≥ 128 cm/s have low NO metabolite levels ( value calculated using t-test). The mean and standard deviation were 31.56 ± 6.26 μM in children with TAMMV < 128 cm/s and 27.27 ± 4.09 μM in children with TAMMV ≥ 128 cm/s.

(a)

(b)