Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease

Figure 3

Association of hematological, biochemical, and immunological biomarkers in children with HbSC, using elevated TAMMV as defined by Viera and colleagues (2014). (a) Children with HbSC with TAMMV ≥ 143.50 cm/s have low hemoglobin levels ( value calculated using t-test). The mean and standard deviation were 11.56 ± 0.89 g/dL in children with TAMMV < 143.5 cm/s and 10.65 ± 0.78 g/dL in children with TAMMV ≥ 143.5 cm/s. (b) Children with HbSC with TAMMV ≥ 143.50 cm/s have low hematocrit levels ( value calculated using t-test). The mean and standard deviation were 33.32 ± 2.71% in children with TAMMV < 143.5 cm/s and 30.51 ± 2.76% in children with TAMMV ≥ 143.5 cm/s. (c) Children with HbSC with TAMMV ≥ 143.50 cm/s have higher ferritin levels ( value calculated using Mann–Whitney). The median and 25th and 75th percentiles were 102.1 (59.53–127.5) ηg/mL in children with TAMMV < 143.5 cm/s and 151.8 (106.6–224.3) ηg/mL in children with TAMMV ≥ 143.5 cm/s.

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