Are Fusion Transcripts in Relapsed/Metastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?

Figure 3

Enrichment map visualizing results of GSEA analysis for cases with the presence/absence of the CD274-PDCD1LG2 fusion. Seven oncogenic signatures inferred from our previous studies [10, 11] were tested, and five resulted a significant difference (oncogenic signature = node). Node size: number of genes in the gene set. Node color: red = enriched in cases harboring the CD274-PDCD1LG2 fusion. Blue = enriched in cases not harboring the fusion. Edges: connect significantly overlapping gene sets (width reflects the degree of the overlap).