Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies.

Study	Nature of study	Number of patients (T/C)	Male/female	Age (T/C)	Unresectable treatment	Antiviral therapy	Follow-up (months)	Outcomes
Toyoda et al. 2012	Retrospective cohort	81 (21/60)	67/14	60.3/60.6	TACE	LAM, ETV, ADV	19.3	OS, PFS
Yoshida et al. 2008	Retrospective cohort	104 (33/71)	78/26	57/59	RFA	LAM	NA	OS, RFS
Zhu et al. 2015	Retrospective cohort	176 (58/118)	152/24	48.7/49.8	TACE	LAM, ADV	NA	OS, PFS
Xu et al. 2014	RCT	181 (92/89)	164/17	56.0/55.1	TACE	LAM	24	OS, PFS
Sohn et al. 2016	Retrospective cohort	228 (125/103)	170/58	55.0/55.2	RFA	LAM, ETV, CLV, ADV, TDF	96	OS
Zhou et al. 2015	Retrospective cohort	224 (80/144)	209/15	48.0/50.5	TACE	LAM, ADV, ETV	9.9	OS

RCT: randomized controlled trials; TACE: transarterial chemoembolization; RFA: radiofrequency ablation; OS: overall survival; PFS: progression-free survival; RFS: recurrence-free survival rate.