Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients

Table 2

Comparison of tacrolimus concentration/dose ratios in different groups of CYP3A5, IL-18, and IL-10 polymorphisms at different times after drug initiation.

Gene	Locus	Genotype	Week 1		Week 2		Week 3		Week 4
			C/D ratio		C/D ratio		C/D ratio		C/D ratio
CYP3A5	rs776746	GG		0.005		0.008		0.003		<0.001
		AG+AA
IL-18	rs5744247	GG+CG		0.002		0.004		0.005		0.026
		CC
IL-18	rs1946518	CC		0.007		0.018		0.019		0.079
		CA
		AA
IL-10	rs1800896	AA		0.027		0.034		0.24		0.24
		AG
IL-10	rs1800872	AA		0.985		0.863		0.909		0.605
		CA+CC
IL-10	rs3021097	CC+TC		1.000		0.909		0.879		0.634
		TT